DegronMD

Uniprot ID: Q2TAA8

Source protein: Translin-associated factor X-interacting protein 1

Source gene: TSNAXIP1

Class: DEG_APCC_DBOX_1

Location: 588:596

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9795

ASA_SCORE: 35.8

COIL: 0.2058

CONS_SCORE: 0.3981

DSS_SCORE: 0.4015

HELIX: 0.7888

FCONS_SCORE: 1.3625

RIG_SCORE: 0.7383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E581Q	TCGA-D8-A1JA	BRCA	TCGA	LRGGLMTID	DEG_APCC_DBOX_1	0.1389
p.E582K	TCGA-EE-A2MR	SKCM	TCGA	LRGGLMTID	DEG_APCC_DBOX_1	0.1667
p.W579R	DO234149	ESAD	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	0.0833
p.R592H	DO233191	GACA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	0.8244
p.R592H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LRGGLMTID	DEG_APCC_DBOX_1	0.8244
p.R592H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	0.8244
p.G578S	DO14750	HNSC	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	0.0556
p.S603I	DO229037	LICA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	0.1389
p.M578T	DO229253	THCA	ICGC	LRGGLMTID	DEG_APCC_DBOX_1	0.0556
p.E581D	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	0.1389
p.E581D	LNCaP-Clone-FGC	prostate	COSMIC	LRGGLMTID	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAA8	Translin-associated factor X-interacting protein 1	DEG_APCC_DBOX_1	588:596	LRGGLMTID	APC,CDC20,FZR1	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons