DegronMD - Q9BQS8(FYCO1)

FUNCTION: May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}.

GO - Biological processes (BP): plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of autophagosome maturation [GO:1901098]

GO - Molecular function (MF): metal ion binding [GO:0046872]

GO - Cellular component (CC): autophagosome [GO:0005776]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosome [GO:0005764]; membrane [GO:0016020]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
DYR	CBL_MET	CBL	FYVE and coiled-coil domain-containing protein 1	1271:1273	More..
MRLELDQLE	DEG_APCC_DBOX_1	APC,CDC20,FZR1	FYVE and coiled-coil domain-containing protein 1	235:243	More..
LPETPTET	DEG_SCF_FBW7_1	FBXW7	FYVE and coiled-coil domain-containing protein 1	1298:1305	More..
LTPEDT	DEG_SCF_FBW7_1	FBXW7	FYVE and coiled-coil domain-containing protein 1	1322:1327	More..

Showing 1 to 4 of 4 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R236Q	TCGA-B5-A0JY	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.R236Q	DO43041	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.T1301K	DO229034	LICA	ICGC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation altering degron motif	0.7306
p.E238A	DO52365	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01735	Biliary Tract Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01471	Chronic Myelogenous Leukemia	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01494	Glioblastoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.S1321L	TCGA-AJ-A3EK	UCEC	TCGA	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.3056
p.V244M	TCGA-DD-AAEG	LIHC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.V244M	DO52271	LIHC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.P1274T	DO229037	LICA	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.3056
p.R245L	TCGA-33-4586	LUSC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.R245L	DO27318	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.D233H	DO224768	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.R245W	DO35290	PACA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.T1320A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.2778
p.T1320A	PF-382	haematopoietic and lymphoid tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.2778
p.P1275L	MC-IXC	autonomic ganglia	COSMIC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 82 entries

Previous1 2 3 4 5Next

Kaplan plot for FYCO1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FYCO1

UniProt ID: Q9BQS8

Entrez ID: 79443

Protein name: FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FYCO1 in