DegronMD - Q9BQS8(FYCO1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R252S	TCGA-09-2044	OV	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252S	DO28923	OV	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252C	TCGA-2W-A8YY	CESC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252C	TCGA-EO-A3AZ	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252C	DO223732	CESC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252C	DO50078	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R245L	TCGA-33-4586	LUSC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.R245L	DO27318	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.V1279L	TCGA-39-5011	LUSC	TCGA	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1667
p.V1279L	DO27532	LUSC	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1667
p.R250W	TCGA-A6-6653	COAD	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250W	DO10373	COAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.D1277N	TCGA-AA-A010	COAD	TCGA	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.2222
p.S1321L	TCGA-AJ-A3EK	UCEC	TCGA	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.3056
p.A1278T	TCGA-AP-A0LT	UCEC	TCGA	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1944
p.A1278T	TCGA-B5-A0K9	UCEC	TCGA	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1944
p.A1278T	DO42097	UCEC	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1944
p.A1278T	DO42681	UCEC	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1944
p.R236Q	TCGA-B5-A0JY	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.R236Q	DO43041	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.7329
p.R252H	TCGA-B5-A3FC	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	TCGA-CA-6717	COAD	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	DO8264	COAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	DO41871	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	SIDM01051	Ovarian Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	ACH-000936	Ovarian Cancer	CCLE	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.R252H	EFO-27	ovary	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0833
p.V1332M	TCGA-CA-6719	COAD	TCGA	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.1944
p.V1332M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.1944
p.V1332M	ACH-002220	Lymphoma	CCLE	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.1944
p.V1332M	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.1944
p.V244M	TCGA-DD-AAEG	LIHC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.V244M	DO52271	LIHC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.3056
p.L1288F	TCGA-DI-A1BU	UCEC	TCGA	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.0556
p.L1288F	DO42023	UCEC	ICGC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.0556
p.A228T	DO224553	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.A228T	DO1002	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.D233H	DO224768	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.R250Q	DO229010	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250Q	DO229013	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250Q	DO229016	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250Q	DO229003	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250Q	DO229005	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.R250Q	DO234285	ESAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1389
p.E1330G	DO233760	GACA	ICGC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.25
p.T1301K	DO229034	LICA	ICGC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation altering degron motif	0.7306
p.D1276E	DO229035	LICA	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.25
p.P1274T	DO229037	LICA	ICGC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.3056
p.D1309E	DO229041	LICA	ICGC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.2222
p.M253I	DO229054	LICA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0556
p.E238A	DO52365	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01735	Biliary Tract Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01471	Chronic Myelogenous Leukemia	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.E238A	SIDM01494	Glioblastoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.659
p.R245W	DO35290	PACA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.S1294P	DO36556	READ	ICGC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.2222
p.A1312V	SIDM01175	Other Sarcomas	GDSC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1389
p.A1312V	SIDM01175	Other Sarcomas	GDSC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.0556
p.A1312V	ACH-002309	Sarcoma	CCLE	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1389
p.A1312V	ACH-002309	Sarcoma	CCLE	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.0556
p.A1312V	SW684	soft tissue	COSMIC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1389
p.A1312V	SW684	soft tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.0556
p.V1279A	SIDM00964	Non-Cancerous	GDSC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1667
p.V1279A	ACH-001453	Prostate Cancer	CCLE	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1667
p.V1279A	BPH-1	prostate	COSMIC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.1667
p.E251D	SIDM00498	Colorectal Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.E251D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.E251D	SIDM00233	T-Lymphoblastic Leukemia	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.E251D	ATN-1	haematopoietic and lymphoid tissue	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.E251D	SNU-C5	large intestine	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.E251D	EMC-BAC-1	lung	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.1111
p.G1295S	SIDM01052	Ovarian Carcinoma	GDSC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.25
p.G1295S	ACH-000308	Ovarian Cancer	CCLE	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.25
p.G1295S	EFO-21	ovary	COSMIC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.25
p.E1293V	SIDM00217	Colorectal Carcinoma	GDSC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1944
p.E1293V	ACH-000999	Colon/Colorectal Cancer	CCLE	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1944
p.E1293V	SNU-1040	large intestine	COSMIC	LPETPTET	DEG_SCF_FBW7_1	1298:1305	Mutation rewiring degron network	0.1944
p.T1320A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.2778
p.T1320A	PF-382	haematopoietic and lymphoid tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	1322:1327	Mutation rewiring degron network	0.2778
p.P1275L	MC-IXC	autonomic ganglia	COSMIC	DYR	CBL_MET	1271:1273	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FYCO1

UniProt ID: Q9BQS8

Entrez ID: 79443

Protein name: FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FYCO1 in