DegronMD

Uniprot ID: Q9BQS8

Source protein: FYVE and coiled-coil domain-containing protein 1

Source gene: FYCO1

Class: DEG_SCF_FBW7_1

Location: 1322:1327

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 86.35

COIL: 0.8248

CONS_SCORE: 0.4413

DSS_SCORE: 0.7945

HELIX: 0.1415

FCONS_SCORE: 1.0826

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1321L	TCGA-AJ-A3EK	UCEC	TCGA	LTPEDT	DEG_SCF_FBW7_1	0.3056
p.V1332M	TCGA-CA-6719	COAD	TCGA	LTPEDT	DEG_SCF_FBW7_1	0.1944
p.V1332M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPEDT	DEG_SCF_FBW7_1	0.1944
p.V1332M	ACH-002220	Lymphoma	CCLE	LTPEDT	DEG_SCF_FBW7_1	0.1944
p.V1332M	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	0.1944
p.E1330G	DO233760	GACA	ICGC	LTPEDT	DEG_SCF_FBW7_1	0.25
p.A1312V	SIDM01175	Other Sarcomas	GDSC	LTPEDT	DEG_SCF_FBW7_1	0.0556
p.A1312V	ACH-002309	Sarcoma	CCLE	LTPEDT	DEG_SCF_FBW7_1	0.0556
p.A1312V	SW684	soft_tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	0.0556
p.T1320A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LTPEDT	DEG_SCF_FBW7_1	0.2778
p.T1320A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LTPEDT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQS8	FYVE and coiled-coil domain-containing protein 1	DEG_SCF_FBW7_1	1322:1327	LTPEDT	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons