DegronMD

Uniprot ID: Q9BQS8

Source protein: FYVE and coiled-coil domain-containing protein 1

Source gene: FYCO1

Class: DEG_APCC_DBOX_1

Location: 235:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5392

ASA_SCORE: 103.7889

COIL: 0.0443

CONS_SCORE: 0.6035

DSS_SCORE: 0.3498

HELIX: 0.956

FCONS_SCORE: 1.3604

RIG_SCORE: 0.813

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R252S	TCGA-09-2044	OV	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252S	DO28923	OV	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252C	TCGA-2W-A8YY	CESC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252C	TCGA-EO-A3AZ	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252C	DO223732	CESC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252C	DO50078	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R245L	TCGA-33-4586	LUSC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.2778
p.R245L	DO27318	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.2778
p.R250W	TCGA-A6-6653	COAD	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250W	DO10373	COAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R236Q	TCGA-B5-A0JY	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.7329
p.R236Q	DO43041	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.7329
p.R252H	TCGA-B5-A3FC	UCEC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	TCGA-CA-6717	COAD	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	DO8264	COAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	DO41871	UCEC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	SIDM01051	Ovarian Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	ACH-000936	Ovarian Cancer	CCLE	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.R252H	EFO-27	ovary	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	0.0833
p.V244M	TCGA-DD-AAEG	LIHC	TCGA	MRLELDQLE	DEG_APCC_DBOX_1	0.3056
p.V244M	DO52271	LIHC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.3056
p.A228T	DO224553	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.A228T	DO1002	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.D233H	DO224768	BRCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.2778
p.R250Q	DO229010	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250Q	DO229013	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250Q	DO229016	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250Q	DO229003	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250Q	DO229005	COCA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.R250Q	DO234285	ESAD	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.1389
p.M253I	DO229054	LICA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.0556
p.E238A	DO52365	LUSC	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.E238A	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.E238A	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.E238A	SIDM01735	Biliary Tract Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.E238A	SIDM01471	Chronic Myelogenous Leukemia	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.E238A	SIDM01494	Glioblastoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.659
p.R245W	DO35290	PACA	ICGC	MRLELDQLE	DEG_APCC_DBOX_1	0.2778
p.E251D	SIDM00498	Colorectal Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111
p.E251D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111
p.E251D	SIDM00233	T-Lymphoblastic Leukemia	GDSC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111
p.E251D	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111
p.E251D	SNU-C5	large_intestine	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111
p.E251D	EMC-BAC-1	lung	COSMIC	MRLELDQLE	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRLELDQLE

Degron related mutations and impact score

Drug responses associated with FYCO1 mutations

All proteins holding degron of MRLELDQLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQS8	FYVE and coiled-coil domain-containing protein 1	DEG_APCC_DBOX_1	235:243	MRLELDQLE	APC,CDC20,FZR1	0.5392	More...