DegronMD

Uniprot ID: Q9BQS8

Source protein: FYVE and coiled-coil domain-containing protein 1

Source gene: FYCO1

Class: DEG_SCF_FBW7_1

Location: 1298:1305

E3 ligase: FBXW7

DEGRON score: 0.6819

ASA_SCORE: 94.2

COIL: 0.911

CONS_SCORE: 0.3994

DSS_SCORE: 0.8279

HELIX: 0.0588

FCONS_SCORE: 0.9451

RIG_SCORE: 0.6164

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1288F	TCGA-DI-A1BU	UCEC	TCGA	LPETPTET	DEG_SCF_FBW7_1	0.0556
p.L1288F	DO42023	UCEC	ICGC	LPETPTET	DEG_SCF_FBW7_1	0.0556
p.T1301K	DO229034	LICA	ICGC	LPETPTET	DEG_SCF_FBW7_1	0.7306
p.D1309E	DO229041	LICA	ICGC	LPETPTET	DEG_SCF_FBW7_1	0.2222
p.S1294P	DO36556	READ	ICGC	LPETPTET	DEG_SCF_FBW7_1	0.2222
p.A1312V	SIDM01175	Other Sarcomas	GDSC	LPETPTET	DEG_SCF_FBW7_1	0.1389
p.A1312V	ACH-002309	Sarcoma	CCLE	LPETPTET	DEG_SCF_FBW7_1	0.1389
p.A1312V	SW684	soft_tissue	COSMIC	LPETPTET	DEG_SCF_FBW7_1	0.1389
p.G1295S	SIDM01052	Ovarian Carcinoma	GDSC	LPETPTET	DEG_SCF_FBW7_1	0.25
p.G1295S	ACH-000308	Ovarian Cancer	CCLE	LPETPTET	DEG_SCF_FBW7_1	0.25
p.G1295S	EFO-21	ovary	COSMIC	LPETPTET	DEG_SCF_FBW7_1	0.25
p.E1293V	SIDM00217	Colorectal Carcinoma	GDSC	LPETPTET	DEG_SCF_FBW7_1	0.1944
p.E1293V	ACH-000999	Colon/Colorectal Cancer	CCLE	LPETPTET	DEG_SCF_FBW7_1	0.1944
p.E1293V	SNU-1040	large_intestine	COSMIC	LPETPTET	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQS8	FYVE and coiled-coil domain-containing protein 1	DEG_SCF_FBW7_1	1298:1305	LPETPTET	FBXW7	0.6819	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons