DegronMD - O75376(NCOR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2243K	TCGA-2H-A9GO	ESCA	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation altering degron motif	0.7306
p.T2243M	TCGA-4Z-AA81	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation altering degron motif	0.7423
p.T2243M	TCGA-A5-A0G2	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation altering degron motif	0.7423
p.F2081I	TCGA-63-A5MW	LUSC	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1389
p.F2081I	TCGA-63-A5MW	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.3056
p.Q2071K	TCGA-A3-3357	KIRC	TCGA	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1944
p.E758G	TCGA-A6-5665	COAD	TCGA	APSTS	DEG_SPOP_SBC_1	760:764	Mutation rewiring degron network	0.2778
p.V2093A	TCGA-A6-6781	COAD	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation altering degron motif	0.5825
p.G1311D	TCGA-AP-A059	UCEC	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1389
p.R44H	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	42:44	Mutation altering degron motif	0.8244
p.R44H	DO42280	UCEC	ICGC	DYR	CBL_MET	42:44	Mutation altering degron motif	0.8244
p.R44H	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	42:44	Mutation altering degron motif	0.8244
p.R44H	ACH-000784	Esophageal Cancer	CCLE	DYR	CBL_MET	42:44	Mutation altering degron motif	0.8244
p.R44H	KYSE-70	oesophagus	COSMIC	DYR	CBL_MET	42:44	Mutation altering degron motif	0.8244
p.H34N	TCGA-AZ-6601	COAD	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1111
p.H34N	DO8119	COAD	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1111
p.F119Y	TCGA-B4-5843	KIRC	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.2222
p.F119Y	DO17781	KIRC	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.2222
p.I2235M	TCGA-BH-A1FC	BRCA	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1944
p.L104P	TCGA-CG-4306	STAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.25
p.L104P	DO38567	STAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.25
p.L1312P	TCGA-CK-5916	COAD	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1111
p.E49K	TCGA-CQ-5331	HNSC	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1944
p.E49K	DO15495	HNSC	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1944
p.S2098L	TCGA-CU-A3YL	BLCA	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.25
p.R2100C	TCGA-D1-A103	UCEC	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1944
p.R2100C	ACH-001061	Colon/Colorectal Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1944
p.F2254S	TCGA-D3-A8GP	SKCM	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.0556
p.S2249C	TCGA-DK-A1AC	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1944
p.L48F	TCGA-DU-6407	LGG	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.2222
p.L48F	DO22295	LGG	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.2222
p.Q2230H	TCGA-DU-7294	LGG	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.0556
p.T2242S	TCGA-DU-8166	LGG	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation altering degron motif	0.6005
p.D1310H	TCGA-E7-A6MD	BLCA	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1667
p.S2069F	TCGA-EB-A85J	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1389
p.S2069F	TCGA-FS-A1ZK	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1389
p.S51N	TCGA-FD-A3SP	BLCA	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1389
p.S51N	DO594	BLCA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1389
p.S103L	TCGA-FI-A2D5	UCEC	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.2222
p.S103L	DO41331	UCEC	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.2222
p.S45P	TCGA-HZ-7922	PAAD	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.3056
p.S45P	DO32755	PAAD	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.3056
p.K107N	TCGA-IB-7651	PAAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.5806
p.K107N	DO46657	PAAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.5806
p.S97T	TCGA-J2-A4AD	LUAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation blocking phosphorylation signal	0.5
p.S97T	DO23915	LUAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation blocking phosphorylation signal	0.5
p.E1309K	TCGA-MA-AA3W	CESC	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1944
p.G2251C	TCGA-QK-A6VB	HNSC	TCGA	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1389
p.S54L	TCGA-SY-A9G5	BLCA	TCGA	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0556
p.S54L	DO51906	BLCA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0556
p.S2069T	TCGA-VQ-A91D	STAD	TCGA	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1389
p.V114D	TCGA-WE-A8ZM	SKCM	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.7785
p.V114D	DO51284	SKCM	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.7785
p.S106L	TCGA-YC-A89H	BLCA	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation blocking phosphorylation signal	0.75
p.S106L	DO51948	BLCA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation blocking phosphorylation signal	0.75
p.G2083R	DO219042	BLCA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1944
p.G2083R	DO219042	BLCA	ICGC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.25
p.S2234F	DO1255	BRCA	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1667
p.S2234F	DO8264	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1667
p.K2231T	DO9002	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.0833
p.R2080H	DO7776	COAD	ICGC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation altering degron motif	0.8244
p.G2238V	DO8514	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.2778
p.R763S	DO219652	KIRP	ICGC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation altering degron motif	0.7427
p.Q36K	DO228948	LICA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1667
p.P2082T	DO228974	LICA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1667
p.P2082T	DO228974	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.2778
p.L1302I	DO228985	LICA	ICGC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation altering degron motif	0.7174
p.L2095I	DO229027	LICA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation altering degron motif	0.7174
p.A53E	DO229027	LICA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0833
p.T32N	DO229032	LICA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0556
p.A124D	DO229031	LICA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.0833
p.E105K	DO50867	LICA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.2778
p.S757N	DO50970	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation rewiring degron network	0.25
p.N2097H	DO231793	LINC	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.2778
p.Q52R	DO48719	LIRI	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.1111
p.R33L	DO32912	PACA	ICGC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0833
p.P762S	DO37699	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation altering degron motif	0.6752
p.Y2087H	DO52402	UCEC	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.3056
p.Y2087H	DO52402	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1389
p.D764Y	DO42568	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation altering degron motif	0.7325
p.S2232Y	DO41133	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.T2244M	DO42665	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation altering degron motif	0.7423
p.H2252Y	SIDM01043	Other Sarcomas	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.H2252Y	SIDM00857	Melanoma	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.H2252Y	SIDM00712	Non-Cancerous	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.H2252Y	SIDM01201	Other Blood Cancers	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.H2252Y	SIDM00713	Mesothelioma	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.S2069P	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1389
p.P109L	SIDM00915	Small Cell Lung Carcinoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.6471
p.P109L	ACH-002173	Lung Cancer	CCLE	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.6471
p.P109L	NCI-H378	lung	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.6471
p.R121C	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.1667
p.R121C	ACH-000825	Lung Cancer	CCLE	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.1667
p.R121C	HOP-92	lung	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation rewiring degron network	0.1667
p.S2253Y	SIDM00193	Colorectal Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation blocking phosphorylation signal	0.5278
p.S2253Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation blocking phosphorylation signal	0.5278
p.S2253Y	SNU-81	large intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation blocking phosphorylation signal	0.5278
p.T757M	SIDM01154	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation rewiring degron network	0.25
p.T757M	ACH-000953	Leukemia	CCLE	APSTS	DEG_SPOP_SBC_1	760:764	Mutation rewiring degron network	0.25
p.T757M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation rewiring degron network	0.25
p.S97F	SIDM00063	Melanoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation blocking phosphorylation signal	0.5
p.R1289S	SIDM00209	Glioblastoma	GDSC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1111
p.R1289S	ACH-002228	Brain Cancer	CCLE	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1111
p.R1289S	D-423MG	central nervous system	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1111
p.S2070L	SIDM01254	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1667
p.S2070L	ACH-000707	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.1667
p.N2083T	ACH-000097	Breast Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1944
p.N2083T	ACH-000097	Breast Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.25
p.N2083Y	ACH-000097	Breast Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	2088:2095	Mutation rewiring degron network	0.1944
p.N2083Y	ACH-000097	Breast Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	2076:2080	Mutation rewiring degron network	0.25
p.R1305S	D-423MG	central nervous system	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.3056
p.G53R	CL-34	large intestine	COSMIC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.0833
p.A39S	NCI-H1651	lung	COSMIC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.25
p.C1290Y	NCI-H1155	lung	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1389
p.A39P	C2BBe1	large intestine	COSMIC	DYR	CBL_MET	42:44	Mutation rewiring degron network	0.25
p.K2232T	CW-2	large intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	2240:2244	Mutation rewiring degron network	0.1111
p.V114M	SNU-1040	large intestine	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	107:115	Mutation altering degron motif	0.6097
p.T773M	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	APSTS	DEG_SPOP_SBC_1	760:764	Mutation substituting flanking lysine	0.1944
p.Q1291H	Ca9-22	upper aerodigestive tract	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	1297:1304	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOR1

UniProt ID: O75376

Entrez ID: 9611

Protein name: Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOR1 in