DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
PPTST
Uniprot ID:
O75376
Source protein:
Nuclear receptor corepressor 1
Source gene:
NCOR1
Class:
DEG_SPOP_SBC_1
Location:
2076:2080
E3 ligase:
SPOP
DEGRON score:
0.9939
ASA_SCORE:
83.82
COIL:
0.9008
CONS_SCORE:
0.3648
DSS_SCORE:
0.726
HELIX:
0.0902
FCONS_SCORE:
1.2056
RIG_SCORE:
0.6184
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F2081I
TCGA-63-A5MW
LUSC
TCGA
PPTST
DEG_SPOP_SBC_1
0.3056
p.Q2071K
TCGA-A3-3357
KIRC
TCGA
PPTST
DEG_SPOP_SBC_1
0.1944
p.S2069F
TCGA-EB-A85J
SKCM
TCGA
PPTST
DEG_SPOP_SBC_1
0.1389
p.S2069F
TCGA-FS-A1ZK
SKCM
TCGA
PPTST
DEG_SPOP_SBC_1
0.1389
p.S2069T
TCGA-VQ-A91D
STAD
TCGA
PPTST
DEG_SPOP_SBC_1
0.1389
p.G2083R
DO219042
BLCA
ICGC
PPTST
DEG_SPOP_SBC_1
0.25
p.R2080H
DO7776
COAD
ICGC
PPTST
DEG_SPOP_SBC_1
0.8244
p.P2082T
DO228974
LICA
ICGC
PPTST
DEG_SPOP_SBC_1
0.2778
p.Y2087H
DO52402
UCEC
ICGC
PPTST
DEG_SPOP_SBC_1
0.1389
p.S2069P
SIDM00845
Burkitt's Lymphoma
GDSC
PPTST
DEG_SPOP_SBC_1
0.1389
p.S2070L
SIDM01254
Burkitt's Lymphoma
GDSC
PPTST
DEG_SPOP_SBC_1
0.1667
p.S2070L
ACH-000707
Lymphoma
CCLE
PPTST
DEG_SPOP_SBC_1
0.1667
p.N2083T
ACH-000097
Breast Cancer
CCLE
PPTST
DEG_SPOP_SBC_1
0.25
p.N2083Y
ACH-000097
Breast Cancer
CCLE
PPTST
DEG_SPOP_SBC_1
0.25
Drug responses associated with NCOR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60292
Signal-induced proliferation-associated 1-like protein 3
DEG_SPOP_SBC_1
125:129
PPTST
SPOP
0.9194
More...
O75376
Nuclear receptor corepressor 1
DEG_SPOP_SBC_1
2076:2080
PPTST
SPOP
0.9939
More...
O96018
Amyloid-beta A4 precursor protein-binding family A member 3
DEG_SPOP_SBC_1
237:241
PPTST
SPOP
0.6594
More...
Q00613
Heat shock factor protein 1
DEG_SPOP_SBC_1
365:369
PPTST
SPOP
0.9967
More...
Q02817
Mucin-2
DEG_SPOP_SBC_1
1549:1553
PPTST
SPOP
0.816
More...
Q02817
Mucin-2
DEG_SPOP_SBC_1
1628:1632
PPTST
SPOP
0.7158
More...
Q15648
Mediator of RNA polymerase II transcription subunit 1
DEG_SPOP_SBC_1
1033:1037
PPTST
SPOP
0.9764
More...
Q96D71
RalBP1-associated Eps domain-containing protein 1
DEG_SPOP_SBC_1
237:241
PPTST
SPOP
0.9554
More...
Q9UKZ4
Teneurin-1
DEG_SPOP_SBC_1
234:238
PPTST
SPOP
0.9932
More...
Q9P2V4
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
DEG_SPOP_SBC_1
348:352
PPTST
SPOP
0.7735
More...
C9JQL5
Putative dispanin subfamily A member 2d
DEG_SPOP_SBC_1
40:44
PPTST
SPOP
0.6181
More...
Q96N23
Cilia- and flagella-associated protein 54
DEG_SPOP_SBC_1
25:29
PPTST
SPOP
0.9906
More...