DegronMD

Uniprot ID: O75376

Source protein: Nuclear receptor corepressor 1

Source gene: NCOR1

Class: DEG_SPOP_SBC_1

Location: 2076:2080

E3 ligase: SPOP

DEGRON score: 0.9939

ASA_SCORE: 83.82

COIL: 0.9008

CONS_SCORE: 0.3648

DSS_SCORE: 0.726

HELIX: 0.0902

FCONS_SCORE: 1.2056

RIG_SCORE: 0.6184

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2080H	DO7776	COAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.8244
p.F2081I	TCGA-63-A5MW	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.P2082T	DO228974	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	0.2778
p.G2083R	DO219042	BLCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.25
p.N2083T	ACH-000097	Breast Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.25
p.N2083Y	ACH-000097	Breast Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.25
p.Q2071K	TCGA-A3-3357	KIRC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1944
p.S2070L	SIDM01254	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1667
p.S2070L	ACH-000707	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	0.1667
p.S2069F	TCGA-EB-A85J	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	0.1389
p.S2069F	TCGA-FS-A1ZK	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	0.1389
p.S2069T	TCGA-VQ-A91D	STAD	TCGA	PPTST	DEG_SPOP_SBC_1	0.1389
p.Y2087H	DO52402	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1389
p.S2069P	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1389

Showing 1 to 14 of 14 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons