MED1
UniProt ID: Q15648
Entrez ID: 5469
Protein name: Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Medi...
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.
View more >>
GO - Biological processes (BP):
androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [...
androgen biosynthetic process [GO:0006702]; angiogenesis [GO:0001525]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of interferon-gamma-mediated signaling pathway [GO:0060335]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; protein import into nucleus [GO:0006606]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; RNA polymerase II preinitiation complex assembly [GO:0051123]; thyroid hormone generation [GO:0006590]; thyroid hormone mediated signaling pathway [GO:0002154]; ventricular trabecula myocardium morphogenesis [GO:0003222]
View more >>
GO - Molecular function (MF):
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; estrogen receptor binding [GO:0030331]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; peroxisome proliferator...
chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor binding [GO:0140297]; estrogen receptor binding [GO:0030331]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; nuclear receptor coactivator activity [GO:0030374]; peroxisome proliferator activated receptor binding [GO:0042975]; promoter-specific chromatin binding [GO:1990841]; protein-containing complex binding [GO:0044877]; retinoic acid receptor binding [GO:0042974]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription coactivator binding [GO:0001223]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; vitamin D receptor binding [GO:0042809]
View more >>
GO - Cellular component (CC):
core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
core mediator complex [GO:0070847]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
View more >>
MED1
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MED1 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc