DegronMD

Uniprot ID: Q15648

Source protein: Mediator of RNA polymerase II transcription subunit 1

Source gene: MED1

Class: DEG_SCF_FBW7_1

Location: 1212:1219

E3 ligase: FBXW7

DEGRON score: 0.9932

ASA_SCORE: 91.1375

COIL: 0.9688

CONS_SCORE: 0.3834

DSS_SCORE: 0.7408

HELIX: 0.0149

FCONS_SCORE: 1.0087

RIG_SCORE: 0.5285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1224L	TCGA-64-1677	LUAD	TCGA	VPGTPPSS	DEG_SCF_FBW7_1	0.1944
p.P1224L	DO23996	LUAD	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.1944
p.S1227L	TCGA-DK-A3WW	BLCA	TCGA	VPGTPPSS	DEG_SCF_FBW7_1	0.5556
p.S1227L	DO481	BLCA	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.5556
p.P1208A	TCGA-E5-A4TZ	BLCA	TCGA	VPGTPPSS	DEG_SCF_FBW7_1	0.2222
p.P1208A	DO44055	BLCA	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.2222
p.S1218C	TCGA-G2-A2EF	BLCA	TCGA	VPGTPPSS	DEG_SCF_FBW7_1	0.7541
p.S1218C	DO726	BLCA	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.7541
p.T1215N	DO228926	LICA	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.8166
p.P1208Q	DO228952	LICA	ICGC	VPGTPPSS	DEG_SCF_FBW7_1	0.2222
p.I1225F	SIDM00654	Small Cell Lung Carcinoma	GDSC	VPGTPPSS	DEG_SCF_FBW7_1	0.1667
p.I1225F	ACH-000866	Lung Cancer	CCLE	VPGTPPSS	DEG_SCF_FBW7_1	0.1667
p.I1225F	NCI-H1048	lung	COSMIC	VPGTPPSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SCF_FBW7_1	1212:1219	VPGTPPSS	FBXW7	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons