DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PFTPPTS
Uniprot ID:
Q15648
Source protein:
Mediator of RNA polymerase II transcription subunit 1
Source gene:
MED1
Class:
DEG_SCF_FBW7_1
Location:
1030:1036
E3 ligase:
FBXW7
DEGRON score:
0.9893
ASA_SCORE:
95.0857
COIL:
0.966
CONS_SCORE:
0.3978
DSS_SCORE:
0.8089
HELIX:
0.0104
FCONS_SCORE:
1.0554
RIG_SCORE:
0.5128
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H1024Y
TCGA-B5-A11E
UCEC
TCGA
PFTPPTS
DEG_SCF_FBW7_1
0.1667
p.H1024Y
DO41644
UCEC
ICGC
PFTPPTS
DEG_SCF_FBW7_1
0.1667
Drug responses associated with MED1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PFTPPTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15648
Mediator of RNA polymerase II transcription subunit 1
DEG_SCF_FBW7_1
1030:1036
PFTPPTS
FBXW7
0.9893
More...