DegronMD

Uniprot ID: Q15648

Source protein: Mediator of RNA polymerase II transcription subunit 1

Source gene: MED1

Class: DEG_SCF_FBW7_1

Location: 733:739

E3 ligase: FBXW7

DEGRON score: 0.9255

ASA_SCORE: 103.6429

COIL: 0.9576

CONS_SCORE: 0.3836

DSS_SCORE: 0.6048

HELIX: 0.0199

FCONS_SCORE: 0.9406

RIG_SCORE: 0.6966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D725N	TCGA-IR-A3LH	CESC	TCGA	LDTPHIT	DEG_SCF_FBW7_1	0.1111
p.D725N	DO44381	CESC	ICGC	LDTPHIT	DEG_SCF_FBW7_1	0.1111
p.P749L	DO23504	LINC	ICGC	LDTPHIT	DEG_SCF_FBW7_1	0.0556
p.P748R	DO220896	MELA	ICGC	LDTPHIT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SCF_FBW7_1	733:739	LDTPHIT	FBXW7	0.9255	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons