DegronMD

Uniprot ID: Q9UKZ4

Source protein: Teneurin-1

Source gene: TENM1

Class: DEG_SPOP_SBC_1

Location: 234:238

E3 ligase: SPOP

DEGRON score: 0.9932

ASA_SCORE: 83.58

COIL: 0.9286

CONS_SCORE: 0.3578

DSS_SCORE: 0.7053

HELIX: 0.032

FCONS_SCORE: 1.3394

RIG_SCORE: 0.5442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q239H	TCGA-09-2044	OV	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.Q239H	DO28923	OV	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.R224H	TCGA-AX-A2HC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.0556
p.R224H	DO41572	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.0556
p.A231T	TCGA-BG-A222	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.25
p.A231T	DO42977	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.25
p.P229T	TCGA-DD-AAD0	LIHC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1944
p.P229T	DO52217	LIHC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.T236A	TCGA-EE-A29P	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	0.7139
p.T236A	DO37916	SKCM	ICGC	PPTST	DEG_SPOP_SBC_1	0.7139
p.Q239R	TCGA-FI-A2D5	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.Q239R	DO41331	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.P229Q	TCGA-O2-A52V	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1944
p.P229Q	DO219223	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.P227T	DO229025	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	0.1389
p.S247N	DO219878	SKCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.A230V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	0.2222
p.A230V	ACH-000983	Leukemia	CCLE	PPTST	DEG_SPOP_SBC_1	0.2222
p.A230V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPTST	DEG_SPOP_SBC_1	0.2222
p.P235S	SIDM01187	Breast Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.5641
p.P235S	UACC-812	breast	COSMIC	PPTST	DEG_SPOP_SBC_1	0.5641
p.S241L	ACH-001991	Primary	CCLE	PPTST	DEG_SPOP_SBC_1	0.25
p.A230T	ACH-002509	Skin Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons