DegronMD

Uniprot ID: Q00613

Source protein: Heat shock factor protein 1

Source gene: HSF1

Class: DEG_SPOP_SBC_1

Location: 365:369

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 81.62

COIL: 0.944

CONS_SCORE: 0.3427

DSS_SCORE: 0.7003

HELIX: 0.0348

FCONS_SCORE: 1.1026

RIG_SCORE: 0.5553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P365Q	TCGA-BQ-7049	KIRP	TCGA	PPTST	DEG_SPOP_SBC_1	0.7035
p.P365Q	TCGA-CV-7238	HNSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.7035
p.P364S	TCGA-EB-A5SG	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.D373Y	DO229015	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	0.2222
p.L365M	DO232761	PBCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.711
p.E371K	SIDM01722	Non-Cancerous	GDSC	PPTST	DEG_SPOP_SBC_1	0.2778
p.E371K	SIDM00174	Head and Neck Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.2778
p.R360Q	SIDM00315	Glioblastoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1944
p.R360Q	SIDM00808	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1944
p.R360Q	SIDM01254	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1944
p.R360W	SIDM01088	Endometrial Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1944
p.R360W	RL95-2	endometrium	COSMIC	PPTST	DEG_SPOP_SBC_1	0.1944
p.T374S	ACH-002256	Leukemia	CCLE	PPTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons