DegronMD

Uniprot ID: Q9P2V4

Source protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1

Source gene: LRIT1

Class: DEG_SPOP_SBC_1

Location: 348:352

E3 ligase: SPOP

DEGRON score: 0.7735

ASA_SCORE: 77.88

COIL: 0.9058

CONS_SCORE: 0.5033

DSS_SCORE: 0.527

HELIX: 0.0264

FCONS_SCORE: 0.9764

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P349Q	TCGA-18-3416	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.5924
p.P349Q	DO26423	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	0.5924
p.S351F	TCGA-90-A4ED	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.7982
p.S351F	DO45482	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	0.7982
p.P348L	TCGA-99-8028	LUAD	TCGA	PPTST	DEG_SPOP_SBC_1	0.7582
p.P348L	DO23561	LUAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.7582
p.S357N	TCGA-AX-A2HC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1944
p.S357N	DO41572	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.P349T	TCGA-CV-7422	HNSC	TCGA	PPTST	DEG_SPOP_SBC_1	0.5919
p.P349T	DO14447	HNSC	ICGC	PPTST	DEG_SPOP_SBC_1	0.5919
p.S357R	TCGA-DD-AAD3	LIHC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1944
p.S357R	DO52220	LIHC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.A360T	TCGA-IN-A7NR	STAD	TCGA	PPTST	DEG_SPOP_SBC_1	0.1111
p.A360T	DO51744	STAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.1111
p.P349S	DO222662	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	0.5641
p.S342F	DO229446	SKCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.1667
p.V345F	SIDM00565	Oral Cavity Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.25
p.V345F	ACH-001626	Head and Neck Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.25
p.V345F	OSC-20	upper_aerodigestive_tract	COSMIC	PPTST	DEG_SPOP_SBC_1	0.25
p.H354N	SIDM00665	Gastric Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.2778
p.H354N	ACH-000616	Gastric Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.2778
p.H354N	Hs746T	stomach	COSMIC	PPTST	DEG_SPOP_SBC_1	0.2778
p.G356E	ACH-002396	Bone Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.2222
p.G356E	Sarc9371	bone	COSMIC	PPTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons