DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPTST
Uniprot ID:
C9JQL5
Source protein:
Putative dispanin subfamily A member 2d
Source gene:
-
Class:
DEG_SPOP_SBC_1
Location:
40:44
E3 ligase:
SPOP
DEGRON score:
0.6181
ASA_SCORE:
70.8
COIL:
0.7888
CONS_SCORE:
0.5604
DSS_SCORE:
0.4424
HELIX:
0.0254
FCONS_SCORE:
1.1705
RIG_SCORE:
0.684
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60292
Signal-induced proliferation-associated 1-like protein 3
DEG_SPOP_SBC_1
125:129
PPTST
SPOP
0.9194
More...
O75376
Nuclear receptor corepressor 1
DEG_SPOP_SBC_1
2076:2080
PPTST
SPOP
0.9939
More...
O96018
Amyloid-beta A4 precursor protein-binding family A member 3
DEG_SPOP_SBC_1
237:241
PPTST
SPOP
0.6594
More...
Q00613
Heat shock factor protein 1
DEG_SPOP_SBC_1
365:369
PPTST
SPOP
0.9967
More...
Q02817
Mucin-2
DEG_SPOP_SBC_1
1549:1553
PPTST
SPOP
0.816
More...
Q02817
Mucin-2
DEG_SPOP_SBC_1
1628:1632
PPTST
SPOP
0.7158
More...
Q15648
Mediator of RNA polymerase II transcription subunit 1
DEG_SPOP_SBC_1
1033:1037
PPTST
SPOP
0.9764
More...
Q96D71
RalBP1-associated Eps domain-containing protein 1
DEG_SPOP_SBC_1
237:241
PPTST
SPOP
0.9554
More...
Q9UKZ4
Teneurin-1
DEG_SPOP_SBC_1
234:238
PPTST
SPOP
0.9932
More...
Q9P2V4
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
DEG_SPOP_SBC_1
348:352
PPTST
SPOP
0.7735
More...
C9JQL5
Putative dispanin subfamily A member 2d
DEG_SPOP_SBC_1
40:44
PPTST
SPOP
0.6181
More...
Q96N23
Cilia- and flagella-associated protein 54
DEG_SPOP_SBC_1
25:29
PPTST
SPOP
0.9906
More...