DegronMD - Q9P2V4(LRIT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P349Q	TCGA-18-3416	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.5924
p.P349Q	DO26423	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.5924
p.S351F	TCGA-90-A4ED	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7982
p.S351F	DO45482	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7982
p.P348L	TCGA-99-8028	LUAD	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7582
p.P348L	DO23561	LUAD	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7582
p.S357N	TCGA-AX-A2HC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.S357N	DO41572	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.P349T	TCGA-CV-7422	HNSC	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.5919
p.P349T	DO14447	HNSC	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.5919
p.S357R	TCGA-DD-AAD3	LIHC	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.S357R	DO52220	LIHC	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.A360T	TCGA-IN-A7NR	STAD	TCGA	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.A360T	DO51744	STAD	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.P349S	DO222662	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.5641
p.S342F	DO229446	SKCA	ICGC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.V345F	SIDM00565	Oral Cavity Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.V345F	ACH-001626	Head and Neck Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.V345F	OSC-20	upper aerodigestive tract	COSMIC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.25
p.H354N	SIDM00665	Gastric Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.H354N	ACH-000616	Gastric Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.H354N	Hs746T	stomach	COSMIC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.G356E	ACH-002396	Bone Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222
p.G356E	Sarc9371	bone	COSMIC	PPTST	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2222

Kaplan plot for LRIT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRIT1

UniProt ID: Q9P2V4

Entrez ID: 26103

Protein name: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 (Leucine-rich repeat-containing protein 21) (Photoreceptor-associated LRR superfamily protein) (Retina-specific protein PAL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRIT1 in