DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SPOP_SBC_1

Location: 1549:1553

E3 ligase: SPOP

DEGRON score: 0.816

ASA_SCORE: 96.14

COIL: 0.9524

CONS_SCORE: 0.2414

DSS_SCORE: 0.8242

HELIX: 0.0138

FCONS_SCORE: 0.9583

RIG_SCORE: 0.5863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1550N	DO51005	LAML	ICGC	PPTST	DEG_SPOP_SBC_1	0.7055
p.T1555I	DO222510	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	0.2778
p.P1540S	DO229208	THCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.P1540S	DO229245	THCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons