DegronMD

Uniprot ID: O96018

Source protein: Amyloid-beta A4 precursor protein-binding family A member 3

Source gene: APBA3

Class: DEG_SPOP_SBC_1

Location: 237:241

E3 ligase: SPOP

DEGRON score: 0.6594

ASA_SCORE: 73.18

COIL: 0.7868

CONS_SCORE: 0.5636

DSS_SCORE: 0.6624

HELIX: 0.1834

FCONS_SCORE: 0.7744

RIG_SCORE: 0.6619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L231Q	TCGA-3A-A9IR	PAAD	TCGA	PPTST	DEG_SPOP_SBC_1	0.1667
p.L231Q	DO51681	PAAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.1667
p.S233L	TCGA-AX-A1CE	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.6667
p.S233L	DO42280	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.6667
p.R242C	TCGA-B5-A3FC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.R242C	DO41871	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.T241M	TCGA-DF-A2KU	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.7423
p.T241M	DO223286	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.7423
p.R242H	DO228581	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.R247Q	SIDM00264	Ewing's Sarcoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1667
p.R235W	SIDM00225	Melanoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.2778
p.R235Q	ACH-000068	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons