DegronMD - Q96D71(REPS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V231A	TCGA-AP-A0LM	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.V231A	DO43306	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.L242P	TCGA-DK-A6AW	BLCA	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.L242P	DO48566	BLCA	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.P238T	TCGA-MB-A5Y8	SARC	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.5919
p.P238T	DO220204	SARC	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.5919
p.H246Y	DO222576	COCA	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1944
p.H246Y	SIDM01088	Endometrial Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1944
p.H246Y	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1944
p.H246Y	RL95-2	endometrium	COSMIC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1944
p.T241I	DO50393	ESAD	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7078
p.E228K	DO50354	ESAD	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.E228K	DO233240	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.T236N	DO229009	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.T241A	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.T241A	SIDM00461	Acute Myeloid Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.T241A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.T241A	SIDM01519	Head and Neck Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.T241A	ACH-000786	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.T241A	ACH-000992	Head and Neck Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7139
p.E228D	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.E228D	ACH-000786	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.W230R	ACH-001377	Pancreatic Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389

Kaplan plot for REPS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

REPS1

UniProt ID: Q96D71

Entrez ID: 85021

Protein name: RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for REPS1 in