DegronMD

Uniprot ID: Q96D71

Source protein: RalBP1-associated Eps domain-containing protein 1

Source gene: REPS1

Class: DEG_SPOP_SBC_1

Location: 237:241

E3 ligase: SPOP

DEGRON score: 0.9554

ASA_SCORE: 60.86

COIL: 0.844

CONS_SCORE: 0.2807

DSS_SCORE: 0.5171

HELIX: 0.1192

FCONS_SCORE: 0.9387

RIG_SCORE: 0.7019

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V231A	TCGA-AP-A0LM	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.1667
p.V231A	DO43306	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.1667
p.L242P	TCGA-DK-A6AW	BLCA	TCGA	PPTST	DEG_SPOP_SBC_1	0.3056
p.L242P	DO48566	BLCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.P238T	TCGA-MB-A5Y8	SARC	TCGA	PPTST	DEG_SPOP_SBC_1	0.5919
p.P238T	DO220204	SARC	ICGC	PPTST	DEG_SPOP_SBC_1	0.5919
p.H246Y	DO222576	COCA	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.H246Y	SIDM01088	Endometrial Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.1944
p.H246Y	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.1944
p.H246Y	RL95-2	endometrium	COSMIC	PPTST	DEG_SPOP_SBC_1	0.1944
p.T241I	DO50393	ESAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.7078
p.E228K	DO50354	ESAD	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.E228K	DO233240	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.T236N	DO229009	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	0.3056
p.T241A	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.7139
p.T241A	SIDM00461	Acute Myeloid Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	0.7139
p.T241A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	0.7139
p.T241A	SIDM01519	Head and Neck Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.7139
p.T241A	ACH-000786	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	0.7139
p.T241A	ACH-000992	Head and Neck Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.7139
p.E228D	SIDM00845	Burkitt's Lymphoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.0833
p.E228D	ACH-000786	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	0.0833
p.W230R	ACH-001377	Pancreatic Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons