DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_SPOP_SBC_1

Location: 125:129

E3 ligase: SPOP

DEGRON score: 0.9194

ASA_SCORE: 88.44

COIL: 0.96

CONS_SCORE: 0.3284

DSS_SCORE: 0.8148

HELIX: 0.0234

FCONS_SCORE: 0.9017

RIG_SCORE: 0.5475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M117I	TCGA-D3-A2JP	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	0.1111
p.M117I	DO47407	SKCM	ICGC	PPTST	DEG_SPOP_SBC_1	0.1111
p.Q121H	TCGA-EO-A22R	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	0.2222
p.Q121H	DO42713	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	0.2222
p.S116F	DO233652	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.S116F	DO220892	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0833
p.G134V	DO229008	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	0.1944
p.H115Y	DO222743	MELA	ICGC	PPTST	DEG_SPOP_SBC_1	0.0556
p.S135F	SIDM02041	Colorectal Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	0.6111
p.S135P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	0.6111
p.S135P	EN	endometrium	COSMIC	PPTST	DEG_SPOP_SBC_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_SPOP_SBC_1	125:129	PPTST	SPOP	0.9194	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2076:2080	PPTST	SPOP	0.9939	More...
O96018	Amyloid-beta A4 precursor protein-binding family A member 3	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.6594	More...
Q00613	Heat shock factor protein 1	DEG_SPOP_SBC_1	365:369	PPTST	SPOP	0.9967	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1549:1553	PPTST	SPOP	0.816	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1628:1632	PPTST	SPOP	0.7158	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1033:1037	PPTST	SPOP	0.9764	More...
Q96D71	RalBP1-associated Eps domain-containing protein 1	DEG_SPOP_SBC_1	237:241	PPTST	SPOP	0.9554	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	234:238	PPTST	SPOP	0.9932	More...
Q9P2V4	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	348:352	PPTST	SPOP	0.7735	More...
C9JQL5	Putative dispanin subfamily A member 2d	DEG_SPOP_SBC_1	40:44	PPTST	SPOP	0.6181	More...
Q96N23	Cilia- and flagella-associated protein 54	DEG_SPOP_SBC_1	25:29	PPTST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons