DegronMD - Q9UKZ4(TENM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q239H	TCGA-09-2044	OV	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.Q239H	DO28923	OV	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.L21V	TCGA-43-2576	LUSC	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.L21V	DO27005	LUSC	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.3056
p.P291L	TCGA-44-6774	LUAD	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.6471
p.P291L	DO25000	LUAD	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.6471
p.P13T	TCGA-55-8299	LUAD	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.P13T	DO25927	LUAD	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0833
p.N279K	TCGA-86-6851	LUAD	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1667
p.N279K	DO23798	LUAD	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1667
p.K14R	TCGA-AA-3713	COAD	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.2222
p.K14R	DO8400	COAD	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation substituting flanking lysine	0.2222
p.S301F	TCGA-AJ-A3EL	UCEC	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	TCGA-Z2-A8RT	SKCM	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	DO51301	SKCM	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	DO41542	UCEC	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	SIDM00190	Melanoma	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	ACH-002097	Skin Cancer	CCLE	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301F	CP66-MEL	skin	COSMIC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.A275V	TCGA-AP-A056	UCEC	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0556
p.A275V	DO43971	UCEC	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0556
p.P294L	TCGA-AX-A0J0	UCEC	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.P294L	DO41133	UCEC	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.R224H	TCGA-AX-A2HC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.R224H	DO41572	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.P296S	TCGA-BF-A5ES	SKCM	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.P296S	DO220906	MELA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.P296S	DO219456	SKCM	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.A231T	TCGA-BG-A222	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.A231T	DO42977	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.S301T	TCGA-C5-A1MF	CESC	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.S301T	DO6251	CESC	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0833
p.Y280C	TCGA-CD-A4MG	STAD	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1944
p.Y280C	DO233737	GACA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1944
p.Y280C	DO48009	STAD	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1944
p.P229T	TCGA-DD-AAD0	LIHC	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.P229T	DO52217	LIHC	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.S25N	TCGA-DU-6392	LGG	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.818
p.S25N	DO22237	LGG	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.818
p.S25N	SIDM00007	Other Solid Cancers	GDSC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.818
p.S25N	ACH-001550	Skin Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.818
p.S25N	MCC13	skin	COSMIC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.818
p.P291S	TCGA-EE-A181	SKCM	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.5641
p.P291S	TCGA-EE-A3AG	SKCM	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.5641
p.P291S	DO37471	SKCM	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.5641
p.P291S	DO37444	SKCM	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.5641
p.D20N	TCGA-EE-A29D	SKCM	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.D20N	DO38123	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.T236A	TCGA-EE-A29P	SKCM	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation altering degron motif	0.7139
p.T236A	DO37916	SKCM	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation altering degron motif	0.7139
p.S284P	TCGA-EW-A6SD	BRCA	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.3056
p.S284P	DO223936	BRCA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.3056
p.S26Y	TCGA-F5-6814	READ	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.712
p.S26Y	DO36556	READ	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.712
p.Q239R	TCGA-FI-A2D5	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.Q239R	DO41331	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.A22T	TCGA-FI-A2D5	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7139
p.A22T	DO41331	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7139
p.E18K	TCGA-FR-A8YC	SKCM	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.E18K	DO50301	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.P36A	TCGA-IE-A4EH	SARC	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.P36A	DO220151	SARC	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.0556
p.S30T	TCGA-IE-A4EH	SARC	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.S30T	DO220151	SARC	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2222
p.D28N	TCGA-JW-A5VJ	CESC	TCGA	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.D28N	DO49974	CESC	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation rewiring degron network	0.2778
p.P294T	TCGA-L5-A4OE	ESCA	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.P294T	TCGA-N8-A56S	UCS	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.P229Q	TCGA-O2-A52V	LUSC	TCGA	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.P229Q	DO219223	LUSC	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1944
p.L295P	TCGA-R6-A6Y0	ESCA	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.25
p.N279S	TCGA-W5-AA33	CHOL	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1667
p.P290H	TCGA-ZJ-A8QR	CESC	TCGA	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.6583
p.P290H	DO219749	CESC	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.6583
p.S277R	DO5745	BRCA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1111
p.V287M	DO233866	GACA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.6097
p.P227T	DO229025	LICA	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.S298R	DO229045	LICA	ICGC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1667
p.T24I	DO220877	MELA	ICGC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7078
p.S247N	DO219878	SKCA	ICGC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0833
p.Q278K	SIDM01958	Esophageal Carcinoma	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.1389
p.A230V	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.A230V	ACH-000983	Leukemia	CCLE	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.A230V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222
p.P281H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.P281H	ACH-002256	Leukemia	CCLE	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.P281H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2222
p.S284F	SIDM00284	Melanoma	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.3056
p.S284F	ACH-000805	Skin Cancer	CCLE	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.3056
p.S284F	COLO-679	skin	COSMIC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.3056
p.P290S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation altering degron motif	0.5641
p.S26F	SIDM01118	Small Cell Lung Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7982
p.S26F	ACH-002175	Lung Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7982
p.S26F	NCI-H740	lung	COSMIC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7982
p.Y23D	SIDM01118	Small Cell Lung Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7325
p.Y23D	ACH-002175	Lung Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7325
p.Y23D	NCI-H740	lung	COSMIC	AYTSS	DEG_SPOP_SBC_1	22:26	Mutation altering degron motif	0.7325
p.R302Q	SIDM00527	Colorectal Carcinoma	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0556
p.R302Q	ACH-000935	Colon/Colorectal Cancer	CCLE	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0556
p.R302Q	MDST8	large intestine	COSMIC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.0556
p.P294A	SIDM00929	Chondrosarcoma	GDSC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.P294A	CAL-78	bone	COSMIC	NTVYSPPP	CBL_PTK	285:292	Mutation rewiring degron network	0.2778
p.P235S	SIDM01187	Breast Carcinoma	GDSC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation altering degron motif	0.5641
p.P235S	UACC-812	breast	COSMIC	PPTST	DEG_SPOP_SBC_1	234:238	Mutation altering degron motif	0.5641
p.S241L	ACH-001991	Primary	CCLE	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.A230T	ACH-002509	Skin Cancer	CCLE	PPTST	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TENM1

UniProt ID: Q9UKZ4

Entrez ID: 10178

Protein name: Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1) (Teneurin transmembrane protein 1) [Cleaved into: Ten-1 intracellular domain (IDten-1) (Ten-1 ICD); Teneurin C-terminal-associated peptide (TCPA-1) (Ten-1 extracellular domain) (Ten-1 ECD)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TENM1 in