DegronMD

Uniprot ID: Q9UKZ4

Source protein: Teneurin-1

Source gene: TENM1

Class: DEG_SPOP_SBC_1

Location: 22:26

E3 ligase: SPOP

DEGRON score: 0.8921

ASA_SCORE: 73.96

COIL: 0.7848

CONS_SCORE: 0.2231

DSS_SCORE: 0.6382

HELIX: 0.0986

FCONS_SCORE: 0.8194

RIG_SCORE: 0.6587

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L21V	TCGA-43-2576	LUSC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.3056
p.L21V	DO27005	LUSC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.3056
p.P13T	TCGA-55-8299	LUAD	TCGA	AYTSS	DEG_SPOP_SBC_1	0.0833
p.P13T	DO25927	LUAD	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0833
p.K14R	TCGA-AA-3713	COAD	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2222
p.K14R	DO8400	COAD	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.S25N	TCGA-DU-6392	LGG	TCGA	AYTSS	DEG_SPOP_SBC_1	0.818
p.S25N	DO22237	LGG	ICGC	AYTSS	DEG_SPOP_SBC_1	0.818
p.S25N	SIDM00007	Other Solid Cancers	GDSC	AYTSS	DEG_SPOP_SBC_1	0.818
p.S25N	ACH-001550	Skin Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.818
p.S25N	MCC13	skin	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.818
p.D20N	TCGA-EE-A29D	SKCM	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2778
p.D20N	DO38123	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.S26Y	TCGA-F5-6814	READ	TCGA	AYTSS	DEG_SPOP_SBC_1	0.712
p.S26Y	DO36556	READ	ICGC	AYTSS	DEG_SPOP_SBC_1	0.712
p.A22T	TCGA-FI-A2D5	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.7139
p.A22T	DO41331	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.7139
p.E18K	TCGA-FR-A8YC	SKCM	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2222
p.E18K	DO50301	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.P36A	TCGA-IE-A4EH	SARC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.0556
p.P36A	DO220151	SARC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0556
p.S30T	TCGA-IE-A4EH	SARC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2222
p.S30T	DO220151	SARC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.D28N	TCGA-JW-A5VJ	CESC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2778
p.D28N	DO49974	CESC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.T24I	DO220877	MELA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.7078
p.S26F	SIDM01118	Small Cell Lung Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.7982
p.S26F	ACH-002175	Lung Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.7982
p.S26F	NCI-H740	lung	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.7982
p.Y23D	SIDM01118	Small Cell Lung Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.7325
p.Y23D	ACH-002175	Lung Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.7325
p.Y23D	NCI-H740	lung	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01100	Protein c-Fos	DEG_SPOP_SBC_1	336:340	AYTSS	SPOP	0.819	More...
Q9UKZ4	Teneurin-1	DEG_SPOP_SBC_1	22:26	AYTSS	SPOP	0.8921	More...
Q9H0M5	Zinc finger protein 700	DEG_SPOP_SBC_1	316:320	AYTSS	SPOP	0.7192	More...
Q9NXT0	Zinc finger protein 586	DEG_SPOP_SBC_1	216:220	AYTSS	SPOP	0.6961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AYTSS

Degron related mutations and impact score

Drug responses associated with TENM1 mutations

All proteins holding degron of AYTSS