DegronMD

Uniprot ID: Q9NXT0

Source protein: Zinc finger protein 586

Source gene: ZNF586

Class: DEG_SPOP_SBC_1

Location: 216:220

E3 ligase: SPOP

DEGRON score: 0.6961

ASA_SCORE: 67.6

COIL: 0.7054

CONS_SCORE: 0.6727

DSS_SCORE: 0.1869

HELIX: 0.1422

FCONS_SCORE: 0.8501

RIG_SCORE: 0.8083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R225K	TCGA-19-5956	GBM	TCGA	AYTSS	DEG_SPOP_SBC_1	0.1944
p.S219Y	TCGA-AA-3819	COAD	TCGA	AYTSS	DEG_SPOP_SBC_1	0.712
p.E207Q	TCGA-BT-A2LD	BLCA	TCGA	AYTSS	DEG_SPOP_SBC_1	0.0833
p.R226S	TCGA-BT-A2LD	BLCA	TCGA	AYTSS	DEG_SPOP_SBC_1	0.1667
p.G230V	TCGA-MI-A75G	LIHC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.0556
p.R225S	TCGA-SY-A9G5	BLCA	TCGA	AYTSS	DEG_SPOP_SBC_1	0.1944
p.L210F	DO51906	BLCA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.1667
p.Y219F	DO222947	BTCA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.7528
p.R230Q	DO222529	ESCA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0556
p.E216G	DO12334	GBM	ICGC	AYTSS	DEG_SPOP_SBC_1	0.7199
p.L207S	DO18938	KIRC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0833
p.V206A	DO229346	LAML	ICGC	AYTSS	DEG_SPOP_SBC_1	0.5
p.V222I	DO229052	LICA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.V222I	DO232761	PBCA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.S227L	DO26419	LUSC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.1389
p.P218S	DO220886	MELA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.6752
p.R230P	DO51257	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0556
p.I207T	DO42023	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0833
p.R217M	DO42608	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.8632
p.G212E	SIDM01325	Pancreatic Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.G212E	ACH-000031	Pancreatic Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.2222
p.Y217C	ACH-001991	Primary	CCLE	AYTSS	DEG_SPOP_SBC_1	0.5976
p.R229C	SNU-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.0833
p.L207V	SNU-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.0833
p.L206R	SNU-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons