DegronMD - P01100(FOS)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N245H	TCGA-13-0903	OV	TCGA	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.0833
p.A276T	TCGA-17-Z000	LUAD	TCGA	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1389
p.A276T	TCGA-EY-A1GK	UCEC	TCGA	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1389
p.A276T	DO42985	UCEC	ICGC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1389
p.A317P	TCGA-44-7660	LUAD	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1944
p.A317P	DO23834	LUAD	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1944
p.P332L	TCGA-49-AAQV	LUAD	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.25
p.P332L	TCGA-49-AAQV	LUAD	TCGA	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.P332L	DO218916	LUAD	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.25
p.P332L	DO218916	LUAD	ICGC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2222
p.P275Q	TCGA-60-2698	LUSC	TCGA	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1111
p.L294I	TCGA-A5-A0G2	UCEC	TCGA	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.2778
p.L294I	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.2778
p.L294I	DO41235	UCEC	ICGC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.2778
p.A336D	TCGA-AP-A059	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7793
p.A336D	DO41361	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation altering degron motif	0.7793
p.V342I	TCGA-AX-A1CE	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.V342I	DO42280	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.2778
p.P326S	TCGA-CQ-A4C6	HNSC	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.6752
p.G312W	TCGA-D3-A3CE	SKCM	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.0556
p.M313I	TCGA-D3-A8GL	SKCM	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.0833
p.M313I	DO50287	SKCM	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.0833
p.T240I	TCGA-DA-A95Z	SKCM	TCGA	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.2222
p.E347K	TCGA-KU-A6H7	HNSC	TCGA	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1389
p.S333C	TCGA-UB-A7MB	LIHC	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2222
p.S333C	TCGA-UB-A7MB	LIHC	TCGA	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.S333C	DO52318	LIHC	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2222
p.S333C	DO52318	LIHC	ICGC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.25
p.E233K	DO52089	HNSC	ICGC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation altering degron motif	0.7022
p.A301T	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.0833
p.A301T	ACH-001518	Endometrial/Uterine Cancer	CCLE	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.0833
p.R287H	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	283:292	Mutation altering degron motif	0.7133
p.A317V	SIDM00845	Burkitt's Lymphoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1944
p.P233A	SIDM00969	Ovarian Carcinoma	GDSC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation altering degron motif	0.7503
p.P326L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.7582
p.P326L	ACH-002256	Leukemia	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.7582
p.P326L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.7582
p.T224I	SIDM00813	Non-Cancerous	GDSC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.1667
p.T224I	ACH-001182	Unknown	CCLE	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.1667
p.T224I	RPMI-6666	haematopoietic and lymphoid tissue	COSMIC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.1667
p.C330Y	SIDM00195	Ewing's Sarcoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.3056
p.C330Y	SIDM00195	Ewing's Sarcoma	GDSC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.C330Y	ACH-002117	Bone Cancer	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.3056
p.C330Y	ACH-002117	Bone Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.C330Y	EW-24	bone	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.3056
p.C330Y	EW-24	bone	COSMIC	AYTSS	DEG_SPOP_SBC_1	336:340	Mutation rewiring degron network	0.1667
p.F298Y	SIDM00638	Cervical Carcinoma	GDSC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1667
p.F298Y	ACH-001360	Cervical Cancer	CCLE	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1667
p.F298Y	MS751	cervix	COSMIC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.1667
p.S278Y	SIDM01394	Kidney Carcinoma	GDSC	SETARSVPDM	DEG_COP1_1	283:292	Mutation blocking phosphorylation signal	0.6389
p.S278Y	ACH-000907	Kidney Cancer	CCLE	SETARSVPDM	DEG_COP1_1	283:292	Mutation blocking phosphorylation signal	0.6389
p.P315R	SIDM00162	Biliary Tract Carcinoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1389
p.P315R	ACH-000268	Bile Duct Cancer	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1389
p.R287C	SIDM01743	Melanoma	GDSC	SETARSVPDM	DEG_COP1_1	283:292	Mutation altering degron motif	0.719
p.P290L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SETARSVPDM	DEG_COP1_1	283:292	Mutation altering degron motif	0.7582
p.R323C	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.8301
p.R323H	SNU-1040	large intestine	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.8244
p.R245H	SNU-1040	large intestine	COSMIC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.0833
p.R245C	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.0833
p.S224G	EFM-192A	breast	COSMIC	VATPESE	DEG_SCF_FBW7_2	230:236	Mutation rewiring degron network	0.1667
p.S328I	NCI-H23	lung	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.7341
p.C294Y	EW-24	bone	COSMIC	SETARSVPDM	DEG_COP1_1	283:292	Mutation rewiring degron network	0.2778

Kaplan plot for FOS in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOS

UniProt ID: P01100

Entrez ID: 2353

Protein name: Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FOS in