DegronMD

Uniprot ID: P01100

Source protein: Protein c-Fos

Source gene: FOS

Class: DEG_SCF_FBW7_1

Location: 322:329

E3 ligase: FBXW7

DEGRON score: 0.959

ASA_SCORE: 74.1875

COIL: 0.736

CONS_SCORE: 0.5077

DSS_SCORE: 0.1212

HELIX: 0.0292

FCONS_SCORE: 1.2593

RIG_SCORE: 0.8424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A317P	TCGA-44-7660	LUAD	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.1944
p.A317P	DO23834	LUAD	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	0.1944
p.P332L	TCGA-49-AAQV	LUAD	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.25
p.P332L	DO218916	LUAD	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	0.25
p.P326S	TCGA-CQ-A4C6	HNSC	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.6752
p.G312W	TCGA-D3-A3CE	SKCM	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.0556
p.M313I	TCGA-D3-A8GL	SKCM	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.0833
p.M313I	DO50287	SKCM	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	0.0833
p.S333C	TCGA-UB-A7MB	LIHC	TCGA	PLCTPVVT	DEG_SCF_FBW7_1	0.2222
p.S333C	DO52318	LIHC	ICGC	PLCTPVVT	DEG_SCF_FBW7_1	0.2222
p.A317V	SIDM00845	Burkitt's Lymphoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	0.1944
p.P326L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	0.7582
p.P326L	ACH-002256	Leukemia	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	0.7582
p.P326L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	0.7582
p.C330Y	SIDM00195	Ewing's Sarcoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	0.3056
p.C330Y	ACH-002117	Bone Cancer	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	0.3056
p.C330Y	EW-24	bone	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	0.3056
p.P315R	SIDM00162	Biliary Tract Carcinoma	GDSC	PLCTPVVT	DEG_SCF_FBW7_1	0.1389
p.P315R	ACH-000268	Bile Duct Cancer	CCLE	PLCTPVVT	DEG_SCF_FBW7_1	0.1389
p.R323C	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	0.8301
p.R323H	SNU-1040	large_intestine	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	0.8244
p.S328I	NCI-H23	lung	COSMIC	PLCTPVVT	DEG_SCF_FBW7_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01100	Protein c-Fos	DEG_SCF_FBW7_1	322:329	PLCTPVVT	FBXW7	0.959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons