DegronMD

Uniprot ID: P01100

Source protein: Protein c-Fos

Source gene: FOS

Class: DEG_SPOP_SBC_1

Location: 336:340

E3 ligase: SPOP

DEGRON score: 0.819

ASA_SCORE: 69.8

COIL: 0.7798

CONS_SCORE: 0.4582

DSS_SCORE: 0.0721

HELIX: 0.062

FCONS_SCORE: 1.0078

RIG_SCORE: 0.8495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P332L	TCGA-49-AAQV	LUAD	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2222
p.P332L	DO218916	LUAD	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.A336D	TCGA-AP-A059	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.7793
p.A336D	DO41361	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.7793
p.V342I	TCGA-AX-A1CE	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2778
p.V342I	DO42280	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.E347K	TCGA-KU-A6H7	HNSC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.1389
p.S333C	TCGA-UB-A7MB	LIHC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.25
p.S333C	DO52318	LIHC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.25
p.C330Y	SIDM00195	Ewing's Sarcoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.1667
p.C330Y	ACH-002117	Bone Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.1667
p.C330Y	EW-24	bone	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons