DegronMD

Uniprot ID: Q9H0M5

Source protein: Zinc finger protein 700

Source gene: ZNF700

Class: DEG_SPOP_SBC_1

Location: 316:320

E3 ligase: SPOP

DEGRON score: 0.7192

ASA_SCORE: 68.08

COIL: 0.7692

CONS_SCORE: 0.4134

DSS_SCORE: 0.3315

HELIX: 0.1744

FCONS_SCORE: 0.6265

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R322H	TCGA-AA-A010	COAD	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2778
p.S320Y	TCGA-D1-A17Q	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.712
p.S320Y	DO41903	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.712
p.G330V	TCGA-D3-A1Q3	SKCM	TCGA	AYTSS	DEG_SPOP_SBC_1	0.0556
p.G330V	DO47509	SKCM	ICGC	AYTSS	DEG_SPOP_SBC_1	0.0556
p.R322C	TCGA-FI-A2D5	UCEC	TCGA	AYTSS	DEG_SPOP_SBC_1	0.2778
p.R322C	DO229052	LICA	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.R322C	DO41331	UCEC	ICGC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.S322T	SIDM00602	Gastric Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.S322T	IM-95	stomach	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.2778
p.H327Y	SIDM00487	Colorectal Carcinoma	GDSC	AYTSS	DEG_SPOP_SBC_1	0.1389
p.H327Y	CCK-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.1389
p.S319T	ACH-000919	Gastric Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.6005
p.S319T	IM-95	stomach	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.6005
p.H324Y	ACH-000963	Colon/Colorectal Cancer	CCLE	AYTSS	DEG_SPOP_SBC_1	0.2222
p.H324Y	CCK-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.2222
p.S326F	COLO-792	skin	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.1667
p.H306Y	CCK-81	large_intestine	COSMIC	AYTSS	DEG_SPOP_SBC_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons