DegronMD

Uniprot ID: P01100

Source protein: Protein c-Fos

Source gene: FOS

Class: DEG_SCF_FBW7_2

Location: 230:236

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 78.3286

COIL: 0.8067

CONS_SCORE: 0.4818

DSS_SCORE: 0.5563

HELIX: 0.1436

FCONS_SCORE: 1.2425

RIG_SCORE: 0.7048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N245H	TCGA-13-0903	OV	TCGA	VATPESE	DEG_SCF_FBW7_2	0.0833
p.T240I	TCGA-DA-A95Z	SKCM	TCGA	VATPESE	DEG_SCF_FBW7_2	0.2222
p.E233K	DO52089	HNSC	ICGC	VATPESE	DEG_SCF_FBW7_2	0.7022
p.P233A	SIDM00969	Ovarian Carcinoma	GDSC	VATPESE	DEG_SCF_FBW7_2	0.7503
p.T224I	SIDM00813	Non-Cancerous	GDSC	VATPESE	DEG_SCF_FBW7_2	0.1667
p.T224I	ACH-001182	Unknown	CCLE	VATPESE	DEG_SCF_FBW7_2	0.1667
p.T224I	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	VATPESE	DEG_SCF_FBW7_2	0.1667
p.R245H	SNU-1040	large_intestine	COSMIC	VATPESE	DEG_SCF_FBW7_2	0.0833
p.R245C	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VATPESE	DEG_SCF_FBW7_2	0.0833
p.S224G	EFM-192A	breast	COSMIC	VATPESE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01100	Protein c-Fos	DEG_SCF_FBW7_2	230:236	VATPESE	FBXW7	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons