DegronMD

Uniprot ID: P01100

Source protein: Protein c-Fos

Source gene: FOS

Class: DEG_COP1_1

Location: 283:292

E3 ligase: COP1

DEGRON score: 0.9931

ASA_SCORE: 78.4

COIL: 0.7424

CONS_SCORE: 0.3464

DSS_SCORE: 0.5074

HELIX: 0.0671

FCONS_SCORE: 1.0391

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A276T	TCGA-17-Z000	LUAD	TCGA	SETARSVPDM	DEG_COP1_1	0.1389
p.A276T	TCGA-EY-A1GK	UCEC	TCGA	SETARSVPDM	DEG_COP1_1	0.1389
p.A276T	DO42985	UCEC	ICGC	SETARSVPDM	DEG_COP1_1	0.1389
p.P275Q	TCGA-60-2698	LUSC	TCGA	SETARSVPDM	DEG_COP1_1	0.1111
p.L294I	TCGA-A5-A0G2	UCEC	TCGA	SETARSVPDM	DEG_COP1_1	0.2778
p.L294I	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	0.2778
p.L294I	DO41235	UCEC	ICGC	SETARSVPDM	DEG_COP1_1	0.2778
p.A301T	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	0.0833
p.A301T	ACH-001518	Endometrial/Uterine Cancer	CCLE	SETARSVPDM	DEG_COP1_1	0.0833
p.R287H	DO232224	PBCA	ICGC	SETARSVPDM	DEG_COP1_1	0.7133
p.F298Y	SIDM00638	Cervical Carcinoma	GDSC	SETARSVPDM	DEG_COP1_1	0.1667
p.F298Y	ACH-001360	Cervical Cancer	CCLE	SETARSVPDM	DEG_COP1_1	0.1667
p.F298Y	MS751	cervix	COSMIC	SETARSVPDM	DEG_COP1_1	0.1667
p.S278Y	SIDM01394	Kidney Carcinoma	GDSC	SETARSVPDM	DEG_COP1_1	0.6389
p.S278Y	ACH-000907	Kidney Cancer	CCLE	SETARSVPDM	DEG_COP1_1	0.6389
p.R287C	SIDM01743	Melanoma	GDSC	SETARSVPDM	DEG_COP1_1	0.719
p.P290L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SETARSVPDM	DEG_COP1_1	0.7582
p.C294Y	EW-24	bone	COSMIC	SETARSVPDM	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01100	Protein c-Fos	DEG_COP1_1	283:292	SETARSVPDM	COP1	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons