DegronMD

Uniprot ID: Q9UKZ4

Source protein: Teneurin-1

Source gene: TENM1

Class: CBL_PTK

Location: 285:292

E3 ligase: CBL

DEGRON score: 0.8562

ASA_SCORE: 81.7625

COIL: 0.9463

CONS_SCORE: 0.2535

DSS_SCORE: 0.4718

HELIX: 0.0139

FCONS_SCORE: 1.0509

RIG_SCORE: 0.6759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P291L	TCGA-44-6774	LUAD	TCGA	NTVYSPPP	CBL_PTK	0.6471
p.P291L	DO25000	LUAD	ICGC	NTVYSPPP	CBL_PTK	0.6471
p.N279K	TCGA-86-6851	LUAD	TCGA	NTVYSPPP	CBL_PTK	0.1667
p.N279K	DO23798	LUAD	ICGC	NTVYSPPP	CBL_PTK	0.1667
p.S301F	TCGA-AJ-A3EL	UCEC	TCGA	NTVYSPPP	CBL_PTK	0.0833
p.S301F	TCGA-Z2-A8RT	SKCM	TCGA	NTVYSPPP	CBL_PTK	0.0833
p.S301F	DO51301	SKCM	ICGC	NTVYSPPP	CBL_PTK	0.0833
p.S301F	DO41542	UCEC	ICGC	NTVYSPPP	CBL_PTK	0.0833
p.S301F	SIDM00190	Melanoma	GDSC	NTVYSPPP	CBL_PTK	0.0833
p.S301F	ACH-002097	Skin Cancer	CCLE	NTVYSPPP	CBL_PTK	0.0833
p.S301F	CP66-MEL	skin	COSMIC	NTVYSPPP	CBL_PTK	0.0833
p.A275V	TCGA-AP-A056	UCEC	TCGA	NTVYSPPP	CBL_PTK	0.0556
p.A275V	DO43971	UCEC	ICGC	NTVYSPPP	CBL_PTK	0.0556
p.P294L	TCGA-AX-A0J0	UCEC	TCGA	NTVYSPPP	CBL_PTK	0.2778
p.P294L	DO41133	UCEC	ICGC	NTVYSPPP	CBL_PTK	0.2778
p.P296S	TCGA-BF-A5ES	SKCM	TCGA	NTVYSPPP	CBL_PTK	0.2222
p.P296S	DO220906	MELA	ICGC	NTVYSPPP	CBL_PTK	0.2222
p.P296S	DO219456	SKCM	ICGC	NTVYSPPP	CBL_PTK	0.2222
p.S301T	TCGA-C5-A1MF	CESC	TCGA	NTVYSPPP	CBL_PTK	0.0833
p.S301T	DO6251	CESC	ICGC	NTVYSPPP	CBL_PTK	0.0833
p.Y280C	TCGA-CD-A4MG	STAD	TCGA	NTVYSPPP	CBL_PTK	0.1944
p.Y280C	DO233737	GACA	ICGC	NTVYSPPP	CBL_PTK	0.1944
p.Y280C	DO48009	STAD	ICGC	NTVYSPPP	CBL_PTK	0.1944
p.P291S	TCGA-EE-A181	SKCM	TCGA	NTVYSPPP	CBL_PTK	0.5641
p.P291S	TCGA-EE-A3AG	SKCM	TCGA	NTVYSPPP	CBL_PTK	0.5641
p.P291S	DO37471	SKCM	ICGC	NTVYSPPP	CBL_PTK	0.5641
p.P291S	DO37444	SKCM	ICGC	NTVYSPPP	CBL_PTK	0.5641
p.S284P	TCGA-EW-A6SD	BRCA	TCGA	NTVYSPPP	CBL_PTK	0.3056
p.S284P	DO223936	BRCA	ICGC	NTVYSPPP	CBL_PTK	0.3056
p.P294T	TCGA-L5-A4OE	ESCA	TCGA	NTVYSPPP	CBL_PTK	0.2778
p.P294T	TCGA-N8-A56S	UCS	TCGA	NTVYSPPP	CBL_PTK	0.2778
p.L295P	TCGA-R6-A6Y0	ESCA	TCGA	NTVYSPPP	CBL_PTK	0.25
p.N279S	TCGA-W5-AA33	CHOL	TCGA	NTVYSPPP	CBL_PTK	0.1667
p.P290H	TCGA-ZJ-A8QR	CESC	TCGA	NTVYSPPP	CBL_PTK	0.6583
p.P290H	DO219749	CESC	ICGC	NTVYSPPP	CBL_PTK	0.6583
p.S277R	DO5745	BRCA	ICGC	NTVYSPPP	CBL_PTK	0.1111
p.V287M	DO233866	GACA	ICGC	NTVYSPPP	CBL_PTK	0.6097
p.S298R	DO229045	LICA	ICGC	NTVYSPPP	CBL_PTK	0.1667
p.Q278K	SIDM01958	Esophageal Carcinoma	GDSC	NTVYSPPP	CBL_PTK	0.1389
p.P281H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NTVYSPPP	CBL_PTK	0.2222
p.P281H	ACH-002256	Leukemia	CCLE	NTVYSPPP	CBL_PTK	0.2222
p.P281H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NTVYSPPP	CBL_PTK	0.2222
p.S284F	SIDM00284	Melanoma	GDSC	NTVYSPPP	CBL_PTK	0.3056
p.S284F	ACH-000805	Skin Cancer	CCLE	NTVYSPPP	CBL_PTK	0.3056
p.S284F	COLO-679	skin	COSMIC	NTVYSPPP	CBL_PTK	0.3056
p.P290S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	NTVYSPPP	CBL_PTK	0.5641
p.R302Q	SIDM00527	Colorectal Carcinoma	GDSC	NTVYSPPP	CBL_PTK	0.0556
p.R302Q	ACH-000935	Colon/Colorectal Cancer	CCLE	NTVYSPPP	CBL_PTK	0.0556
p.R302Q	MDST8	large_intestine	COSMIC	NTVYSPPP	CBL_PTK	0.0556
p.P294A	SIDM00929	Chondrosarcoma	GDSC	NTVYSPPP	CBL_PTK	0.2778
p.P294A	CAL-78	bone	COSMIC	NTVYSPPP	CBL_PTK	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NTVYSPPP

Degron related mutations and impact score

Drug responses associated with TENM1 mutations

All proteins holding degron of NTVYSPPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKZ4	Teneurin-1	CBL_PTK	285:292	NTVYSPPP	CBL	0.8562	More...