DegronMD - O96018(APBA3)

APBA3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L231Q	TCGA-3A-A9IR	PAAD	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.L231Q	DO51681	PAAD	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.S233L	TCGA-AX-A1CE	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation blocking phosphorylation signal	0.6667
p.S233L	DO42280	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation blocking phosphorylation signal	0.6667
p.R242C	TCGA-B5-A3FC	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.R242C	DO41871	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.T241M	TCGA-DF-A2KU	UCEC	TCGA	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7423
p.T241M	DO223286	UCEC	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation altering degron motif	0.7423
p.R242H	DO228581	GACA	ICGC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.R247Q	SIDM00264	Ewing's Sarcoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1667
p.R235W	SIDM00225	Melanoma	GDSC	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.R235Q	ACH-000068	Lymphoma	CCLE	PPTST	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc