DegronMD

Uniprot ID: O75376

Source protein: Nuclear receptor corepressor 1

Source gene: NCOR1

Class: DEG_SCF_FBW7_1

Location: 2088:2095

E3 ligase: FBXW7

DEGRON score: 0.9867

ASA_SCORE: 100.575

COIL: 0.9626

CONS_SCORE: 0.3271

DSS_SCORE: 0.6649

HELIX: 0.0139

FCONS_SCORE: 0.991

RIG_SCORE: 0.6692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F2081I	TCGA-63-A5MW	LUSC	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	0.1389
p.V2093A	TCGA-A6-6781	COAD	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	0.5825
p.S2098L	TCGA-CU-A3YL	BLCA	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	0.25
p.R2100C	TCGA-D1-A103	UCEC	TCGA	LVSTPVRT	DEG_SCF_FBW7_1	0.1944
p.R2100C	ACH-001061	Colon/Colorectal Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	0.1944
p.G2083R	DO219042	BLCA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	0.1944
p.P2082T	DO228974	LICA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	0.1667
p.L2095I	DO229027	LICA	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	0.7174
p.N2097H	DO231793	LINC	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	0.2778
p.Y2087H	DO52402	UCEC	ICGC	LVSTPVRT	DEG_SCF_FBW7_1	0.3056
p.N2083T	ACH-000097	Breast Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	0.1944
p.N2083Y	ACH-000097	Breast Cancer	CCLE	LVSTPVRT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75376	Nuclear receptor corepressor 1	DEG_SCF_FBW7_1	2088:2095	LVSTPVRT	FBXW7	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons