DegronMD

Uniprot ID: O75376

Source protein: Nuclear receptor corepressor 1

Source gene: NCOR1

Class: DEG_APCC_DBOX_1

Location: 107:115

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9801

ASA_SCORE: 90.2333

COIL: 0.638

CONS_SCORE: 0.3296

DSS_SCORE: 0.6115

HELIX: 0.3379

FCONS_SCORE: 1.0756

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F119Y	TCGA-B4-5843	KIRC	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.2222
p.F119Y	DO17781	KIRC	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.2222
p.L104P	TCGA-CG-4306	STAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.25
p.L104P	DO38567	STAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.25
p.S103L	TCGA-FI-A2D5	UCEC	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.2222
p.S103L	DO41331	UCEC	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.2222
p.K107N	TCGA-IB-7651	PAAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.5806
p.K107N	DO46657	PAAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.5806
p.S97T	TCGA-J2-A4AD	LUAD	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.5
p.S97T	DO23915	LUAD	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.5
p.V114D	TCGA-WE-A8ZM	SKCM	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.7785
p.V114D	DO51284	SKCM	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.7785
p.S106L	TCGA-YC-A89H	BLCA	TCGA	KRPRLEQVS	DEG_APCC_DBOX_1	0.75
p.S106L	DO51948	BLCA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.75
p.A124D	DO229031	LICA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.0833
p.E105K	DO50867	LICA	ICGC	KRPRLEQVS	DEG_APCC_DBOX_1	0.2778
p.P109L	SIDM00915	Small Cell Lung Carcinoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	0.6471
p.P109L	ACH-002173	Lung Cancer	CCLE	KRPRLEQVS	DEG_APCC_DBOX_1	0.6471
p.P109L	NCI-H378	lung	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	0.6471
p.R121C	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	0.1667
p.R121C	ACH-000825	Lung Cancer	CCLE	KRPRLEQVS	DEG_APCC_DBOX_1	0.1667
p.R121C	HOP-92	lung	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	0.1667
p.S97F	SIDM00063	Melanoma	GDSC	KRPRLEQVS	DEG_APCC_DBOX_1	0.5
p.V114M	SNU-1040	large_intestine	COSMIC	KRPRLEQVS	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75376	Nuclear receptor corepressor 1	DEG_APCC_DBOX_1	107:115	KRPRLEQVS	APC,CDC20,FZR1	0.9801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons