DegronMD

Uniprot ID: O75376

Source protein: Nuclear receptor corepressor 1

Source gene: NCOR1

Class: DEG_SCF_FBW7_1

Location: 1297:1304

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 96.725

COIL: 0.9488

CONS_SCORE: 0.354

DSS_SCORE: 0.5719

HELIX: 0.0225

FCONS_SCORE: 1.1209

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1311D	TCGA-AP-A059	UCEC	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	0.1389
p.L1312P	TCGA-CK-5916	COAD	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	0.1111
p.D1310H	TCGA-E7-A6MD	BLCA	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	0.1667
p.E1309K	TCGA-MA-AA3W	CESC	TCGA	MQGTPRAT	DEG_SCF_FBW7_1	0.1944
p.L1302I	DO228985	LICA	ICGC	MQGTPRAT	DEG_SCF_FBW7_1	0.7174
p.R1289S	SIDM00209	Glioblastoma	GDSC	MQGTPRAT	DEG_SCF_FBW7_1	0.1111
p.R1289S	ACH-002228	Brain Cancer	CCLE	MQGTPRAT	DEG_SCF_FBW7_1	0.1111
p.R1289S	D-423MG	central_nervous_system	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	0.1111
p.R1305S	D-423MG	central_nervous_system	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	0.3056
p.C1290Y	NCI-H1155	lung	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	0.1389
p.Q1291H	Ca9-22	upper_aerodigestive_tract	COSMIC	MQGTPRAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75376	Nuclear receptor corepressor 1	DEG_SCF_FBW7_1	1297:1304	MQGTPRAT	FBXW7	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons