DegronMD - Q8TDC0(MYOZ3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A13T	TCGA-AZ-4323	COAD	TCGA	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.25
p.A13T	DO7886	COAD	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.25
p.A13T	DO233903	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.25
p.N189Y	TCGA-EE-A2MR	SKCM	TCGA	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.3056
p.N189Y	DO37819	SKCM	ICGC	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.3056
p.G181V	TCGA-ER-A19P	SKCM	TCGA	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.0833
p.G181V	DO47623	SKCM	ICGC	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.0833
p.V32M	TCGA-G7-7501	KIRP	TCGA	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.1111
p.V32M	DO20909	KIRP	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.1111
p.V32M	DO33904	PACA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.1111
p.V32M	DO229542	UTCA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.1111
p.T23M	TCGA-HU-A4G9	STAD	TCGA	DLTEPVPTL	DEG_COP1_1	16:24	Mutation altering degron motif	0.7423
p.T23M	DO47789	STAD	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation altering degron motif	0.7423
p.S187I	TCGA-IB-7651	PAAD	TCGA	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.25
p.S187I	DO46657	PAAD	ICGC	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.25
p.P188T	TCGA-NC-A5HT	LUSC	TCGA	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.2778
p.P188T	DO219205	LUSC	ICGC	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.2778
p.A30T	DO233760	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.1667
p.P23Q	DO233823	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation altering degron motif	0.7035
p.A13S	DO233940	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation rewiring degron network	0.25
p.D190N	DO232224	PBCA	ICGC	DYR	CBL_MET	190:192	Mutation altering degron motif	0.6932
p.K28E	DO229211	THCA	ICGC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation substituting flanking lysine	0.3333
p.G8W	SIDM02050	Colorectal Carcinoma	GDSC	DLTEPVPTL	DEG_COP1_1	16:24	Mutation substituting flanking lysine	0.2222
p.N195I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.25
p.N195I	ACH-000983	Leukemia	CCLE	DYR	CBL_MET	190:192	Mutation rewiring degron network	0.25
p.R192Q	SIDM01472	Hepatocellular Carcinoma	GDSC	DYR	CBL_MET	190:192	Mutation altering degron motif	0.7329
p.R192Q	ACH-000280	Ovarian Cancer	CCLE	DYR	CBL_MET	190:192	Mutation altering degron motif	0.7329
p.R192Q	ACH-000471	Liver Cancer	CCLE	DYR	CBL_MET	190:192	Mutation altering degron motif	0.7329
p.S9N	ACH-000986	Colon/Colorectal Cancer	CCLE	DLTEPVPTL	DEG_COP1_1	16:24	Mutation substituting flanking lysine	0.25

Kaplan plot for MYOZ3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYOZ3

UniProt ID: Q8TDC0

Entrez ID: 91977

Protein name: Myozenin-3 (Calsarcin-3) (FATZ-related protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYOZ3 in