DegronMD

Uniprot ID: Q8TDC0

Source protein: Myozenin-3

Source gene: MYOZ3

Class: DEG_COP1_1

Location: 16:24

E3 ligase: COP1

DEGRON score: 0.7963

ASA_SCORE: 84.3222

COIL: 0.8637

CONS_SCORE: 0.5764

DSS_SCORE: 0.4428

HELIX: 0.088

FCONS_SCORE: 0.8451

RIG_SCORE: 0.7432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A13T	TCGA-AZ-4323	COAD	TCGA	DLTEPVPTL	DEG_COP1_1	0.25
p.A13T	DO7886	COAD	ICGC	DLTEPVPTL	DEG_COP1_1	0.25
p.A13T	DO233903	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	0.25
p.V32M	TCGA-G7-7501	KIRP	TCGA	DLTEPVPTL	DEG_COP1_1	0.1111
p.V32M	DO20909	KIRP	ICGC	DLTEPVPTL	DEG_COP1_1	0.1111
p.V32M	DO33904	PACA	ICGC	DLTEPVPTL	DEG_COP1_1	0.1111
p.V32M	DO229542	UTCA	ICGC	DLTEPVPTL	DEG_COP1_1	0.1111
p.T23M	TCGA-HU-A4G9	STAD	TCGA	DLTEPVPTL	DEG_COP1_1	0.7423
p.T23M	DO47789	STAD	ICGC	DLTEPVPTL	DEG_COP1_1	0.7423
p.A30T	DO233760	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	0.1667
p.P23Q	DO233823	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	0.7035
p.A13S	DO233940	GACA	ICGC	DLTEPVPTL	DEG_COP1_1	0.25
p.K28E	DO229211	THCA	ICGC	DLTEPVPTL	DEG_COP1_1	0.3333
p.G8W	SIDM02050	Colorectal Carcinoma	GDSC	DLTEPVPTL	DEG_COP1_1	0.2222
p.S9N	ACH-000986	Colon/Colorectal Cancer	CCLE	DLTEPVPTL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDC0	Myozenin-3	DEG_COP1_1	16:24	DLTEPVPTL	COP1	0.7963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons