DegronMD - Q9HCM1(RESF1)

FUNCTION: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. {ECO:0000250|UniProtKB:Q5DTW7}.

GO - Biological processes (BP): negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; positive regulation of DNA methylation-dependent heterochromatin assembly [GO:0090309]

GO - Molecular function (MF): histone binding [GO:0042393]; histone methyltransferase binding [GO:1990226]

GO - Cellular component (CC): nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DYR	CBL_MET	CBL	Retroelement silencing factor 1	210:212	More..
METPSTS	DEG_SCF_FBW7_1	FBXW7	Retroelement silencing factor 1	632:638	More..
PPLY	ITCH	ITCH,NEDD4	Retroelement silencing factor 1	13:16	More..
PPPY	ITCH	ITCH,NEDD4	Retroelement silencing factor 1	279:282	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K8R	SIDM00697	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation blocking ubiquitination signal	0.6389
p.K8R	NCI-H1436	lung	COSMIC	PPLY	ITCH	13:16	Mutation blocking ubiquitination signal	0.6389
p.S648T	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.A10V	SIDM00282	Colorectal Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.25
p.P21L	SIDM01197	Colorectal Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1944
p.P21L	SNU-C1	large intestine	COSMIC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1944
p.L627Q	SIDM01099	Neuroblastoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.1944
p.P7T	SIDM00223	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P7T	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P7T	SIDM00151	Ovarian Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P22L	SIDM00503	Gastric Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P22L	FU97	stomach	COSMIC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.R219H	SIDM00499	Prostate Carcinoma	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389

Showing 1 to 20 of 29 entries

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No resistance data available for this Degron.

Kaplan plot for RESF1 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RESF1

UniProt ID: Q9HCM1

Entrez ID: 55196

Protein name: Retroelement silencing factor 1

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for RESF1 in