DegronMD - Q9HCM1(RESF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R219H	SIDM00499	Prostate Carcinoma	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	SIDM01320	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.R219H	22RV1	prostate	COSMIC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1389
p.K8R	SIDM00697	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation blocking ubiquitination signal	0.6389
p.K8R	NCI-H1436	lung	COSMIC	PPLY	ITCH	13:16	Mutation blocking ubiquitination signal	0.6389
p.P21L	SIDM01197	Colorectal Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1944
p.P21L	SNU-C1	large intestine	COSMIC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1944
p.L627Q	SIDM01099	Neuroblastoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.1944
p.N647S	SIDM01099	Neuroblastoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.0833
p.A10V	SIDM00282	Colorectal Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.25
p.P7T	SIDM00223	Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P7T	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P7T	SIDM00151	Ovarian Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.Y220C	SIDM00151	Ovarian Carcinoma	GDSC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1111
p.Y220C	IGROV-1	ovary	COSMIC	DYR	CBL_MET	210:212	Mutation rewiring degron network	0.1111
p.S648T	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.S648Y	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation blocking phosphorylation signal	0.5
p.N647D	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.0833
p.N647D	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.0833
p.N647D	NCI-H1993	lung	COSMIC	METPSTS	DEG_SCF_FBW7_1	632:638	Mutation rewiring degron network	0.0833
p.P22L	SIDM00503	Gastric Carcinoma	GDSC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667
p.P22L	FU97	stomach	COSMIC	PPLY	ITCH	13:16	Mutation rewiring degron network	0.1667

Kaplan plot for RESF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RESF1

UniProt ID: Q9HCM1

Entrez ID: 55196

Protein name: Retroelement silencing factor 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RESF1 in