DegronMD

Uniprot ID: Q9HCM1

Source protein: Retroelement silencing factor 1

Source gene: RESF1

Class: DEG_SCF_FBW7_1

Location: 632:638

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 95.8286

COIL: 0.9329

CONS_SCORE: 0.3648

DSS_SCORE: 0.6207

HELIX: 0.0353

FCONS_SCORE: 0.9646

RIG_SCORE: 0.6674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L627Q	SIDM01099	Neuroblastoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.1944
p.N647S	SIDM01099	Neuroblastoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.0833
p.S648T	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.S648T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.S648T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.S648Y	SIDM00779	Colorectal Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.S648Y	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.S648Y	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.5
p.N647D	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.0833
p.N647D	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	METPSTS	DEG_SCF_FBW7_1	0.0833
p.N647D	NCI-H1993	lung	COSMIC	METPSTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM1	Retroelement silencing factor 1	DEG_SCF_FBW7_1	632:638	METPSTS	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons