DegronMD - Q5VUB5(FAM171A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D445Y	TCGA-17-Z022	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation rewiring degron network	0.2778
p.T448N	TCGA-44-7662	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.8166
p.T448N	DO229037	LICA	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.8166
p.T448N	DO23597	LUAD	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.8166
p.T452M	TCGA-44-8120	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.8534
p.T452M	DO45402	LUAD	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.8534
p.E800D	TCGA-68-7756	LUSC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.1944
p.E800D	DO26474	LUSC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.1944
p.R486M	TCGA-75-7027	LUAD	TCGA	DYR	CBL_MET	484:486	Mutation altering degron motif	0.8632
p.R486M	DO24811	LUAD	ICGC	DYR	CBL_MET	484:486	Mutation altering degron motif	0.8632
p.D483H	TCGA-93-7348	LUAD	TCGA	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.3056
p.D483H	DO25639	LUAD	ICGC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.3056
p.T804M	TCGA-A5-A0G1	UCEC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.3056
p.T804M	DO42472	UCEC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.3056
p.Q796H	TCGA-A8-A06Q	BRCA	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.0833
p.Q796H	DO1263	BRCA	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.0833
p.T804A	TCGA-AA-A022	COAD	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.3056
p.T804A	DO10647	COAD	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.3056
p.L813M	TCGA-AP-A051	UCEC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.2778
p.L813M	DO42673	UCEC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.2778
p.R474I	TCGA-BH-A1F2	BRCA	TCGA	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0556
p.R474I	DO3400	BRCA	ICGC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0556
p.S443F	TCGA-D3-A8GN	SKCM	TCGA	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation blocking phosphorylation signal	0.6667
p.S443F	DO222753	MELA	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation blocking phosphorylation signal	0.6667
p.S443F	DO51240	SKCM	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation blocking phosphorylation signal	0.6667
p.V805I	TCGA-DU-6407	LGG	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation altering degron motif	0.5965
p.V805I	TCGA-WE-A8ZX	SKCM	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation altering degron motif	0.5965
p.V805I	DO22295	LGG	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation altering degron motif	0.5965
p.V805I	DO51291	SKCM	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation altering degron motif	0.5965
p.S820L	TCGA-EB-A5UM	SKCM	TCGA	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.0833
p.S820L	DO47282	SKCM	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation rewiring degron network	0.0833
p.D445N	TCGA-FW-A3R5	SKCM	TCGA	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation rewiring degron network	0.2778
p.D445N	DO37406	SKCM	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation rewiring degron network	0.2778
p.D483N	TCGA-HE-7130	KIRP	TCGA	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.3056
p.D483N	DO20776	KIRP	ICGC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.3056
p.R474T	DO228460	BRCA	ICGC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0556
p.D810E	DO229028	LICA	ICGC	VCTPEDS	DEG_SCF_FBW7_1	805:811	Mutation altering degron motif	0.5647
p.P496H	DO229035	LICA	ICGC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0556
p.E462K	DO222908	MELA	ICGC	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation rewiring degron network	0.0556
p.V492M	SIDM00875	Breast Carcinoma	GDSC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.1667
p.Q495K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0833
p.Q495K	ACH-000878	Lung Cancer	CCLE	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0833
p.Q495K	HCC-15	lung	COSMIC	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.0833
p.E478K	ACH-001346	Head and Neck Cancer	CCLE	DYR	CBL_MET	484:486	Mutation rewiring degron network	0.1667
p.G451E	ACH-002508	Skin Cancer	CCLE	LTPSGT	DEG_SCF_FBW7_1	447:452	Mutation altering degron motif	0.6087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM171A1

UniProt ID: Q5VUB5

Entrez ID: 221061

Protein name: Protein FAM171A1 (Astroprincin) (APCN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM171A1 in