DegronMD

Uniprot ID: Q5VUB5

Source protein: Protein FAM171A1

Source gene: FAM171A1

Class: DEG_SCF_FBW7_1

Location: 447:452

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 59.5667

COIL: 0.863

CONS_SCORE: 0.483

DSS_SCORE: 0.4254

HELIX: 0.077

FCONS_SCORE: 1.2007

RIG_SCORE: 0.653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D445Y	TCGA-17-Z022	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	0.2778
p.T448N	TCGA-44-7662	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	0.8166
p.T448N	DO229037	LICA	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.8166
p.T448N	DO23597	LUAD	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.8166
p.T452M	TCGA-44-8120	LUAD	TCGA	LTPSGT	DEG_SCF_FBW7_1	0.8534
p.T452M	DO45402	LUAD	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.8534
p.S443F	TCGA-D3-A8GN	SKCM	TCGA	LTPSGT	DEG_SCF_FBW7_1	0.6667
p.S443F	DO222753	MELA	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.6667
p.S443F	DO51240	SKCM	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.6667
p.D445N	TCGA-FW-A3R5	SKCM	TCGA	LTPSGT	DEG_SCF_FBW7_1	0.2778
p.D445N	DO37406	SKCM	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.2778
p.E462K	DO222908	MELA	ICGC	LTPSGT	DEG_SCF_FBW7_1	0.0556
p.G451E	ACH-002508	Skin Cancer	CCLE	LTPSGT	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUB5	Protein FAM171A1	DEG_SCF_FBW7_1	447:452	LTPSGT	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons