DegronMD

Uniprot ID: Q5VUB5

Source protein: Protein FAM171A1

Source gene: FAM171A1

Class: DEG_SCF_FBW7_1

Location: 805:811

E3 ligase: FBXW7

DEGRON score: 0.6768

ASA_SCORE: 76.3571

COIL: 0.7554

CONS_SCORE: 0.4445

DSS_SCORE: 0.3061

HELIX: 0.2066

FCONS_SCORE: 1.2347

RIG_SCORE: 0.8126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E800D	TCGA-68-7756	LUSC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.1944
p.E800D	DO26474	LUSC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.1944
p.T804M	TCGA-A5-A0G1	UCEC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.3056
p.T804M	DO42472	UCEC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.3056
p.Q796H	TCGA-A8-A06Q	BRCA	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.0833
p.Q796H	DO1263	BRCA	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.0833
p.T804A	TCGA-AA-A022	COAD	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.3056
p.T804A	DO10647	COAD	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.3056
p.L813M	TCGA-AP-A051	UCEC	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.2778
p.L813M	DO42673	UCEC	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.2778
p.V805I	TCGA-DU-6407	LGG	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.5965
p.V805I	TCGA-WE-A8ZX	SKCM	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.5965
p.V805I	DO22295	LGG	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.5965
p.V805I	DO51291	SKCM	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.5965
p.S820L	TCGA-EB-A5UM	SKCM	TCGA	VCTPEDS	DEG_SCF_FBW7_1	0.0833
p.S820L	DO47282	SKCM	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.0833
p.D810E	DO229028	LICA	ICGC	VCTPEDS	DEG_SCF_FBW7_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUB5	Protein FAM171A1	DEG_SCF_FBW7_1	805:811	VCTPEDS	FBXW7	0.6768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons