DegronMD - Q07954(LRP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2254C	TCGA-A5-A0G1	UCEC	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.0556
p.R2254C	DO42472	UCEC	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.0556
p.L2239M	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.L2239M	DO41361	UCEC	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.P2252H	TCGA-B5-A11J	UCEC	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.P2252H	DO43698	UCEC	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.N4109S	TCGA-D8-A142	BRCA	TCGA	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.0833
p.N4109S	DO4984	BRCA	ICGC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.0833
p.D4096N	TCGA-EE-A3J5	SKCM	TCGA	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5821
p.D4096N	TCGA-XK-AAIW	PRAD	TCGA	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5821
p.D4096N	DO233697	GACA	ICGC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5821
p.D4096N	DO51407	PRAD	ICGC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5821
p.D4096N	DO47331	SKCM	ICGC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5821
p.A2238T	TCGA-ER-A3PL	SKCM	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2222
p.A2238T	TCGA-OR-A5LB	ACC	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2222
p.A2238T	DO37495	SKCM	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2222
p.T2247I	TCGA-FW-A3TU	SKCM	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.T2247I	TCGA-KS-A41J	THCA	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.T2247I	DO37441	SKCM	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.T2247I	DO39762	THCA	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.25
p.P2249S	TCGA-G2-A2EF	BLCA	TCGA	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1944
p.P2249S	DO726	BLCA	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1944
p.P2249L	DO48386	BLCA	ICGC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1944
p.G4104V	DO229045	LICA	ICGC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.2222
p.RA2244RT	DO222843	MELA	ICGC	DYR	CBL_MET	2242:2244	Mutation altering degron motif	0.7876
p.A2240V	SIDM01090	Colorectal Carcinoma	GDSC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2778
p.A2240V	ACH-000943	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2778
p.A2240V	RKO	large intestine	COSMIC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.2778
p.N4110T	SIDM00120	Prostate Carcinoma	GDSC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.0556
p.N4110T	ACH-000979	Prostate Cancer	CCLE	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.0556
p.N4110T	DU-145	prostate	COSMIC	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation rewiring degron network	0.0556
p.P2252T	SIDM00670	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.P2252T	ACH-000270	Pancreatic Cancer	CCLE	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.P2252T	ACH-001098	Pancreatic Cancer	CCLE	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.P2252T	HPAC	pancreas	COSMIC	DYR	CBL_MET	2242:2244	Mutation rewiring degron network	0.1111
p.V4097I	ACH-000170	Non-Cancerous	CCLE	IDVFED	LIG_APCC_ABBA_1	4095:4100	Mutation altering degron motif	0.5965

Kaplan plot for LRP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP1

UniProt ID: Q07954

Entrez ID: 4035

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP1 in