DegronMD

Uniprot ID: Q07954

Source protein: Prolow-density lipoprotein receptor-related protein 1

Source gene: LRP1

Class: LIG_APCC_ABBA_1

Location: 4095:4100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 37.4167

COIL: 0.339

CONS_SCORE: 0.8049

DSS_SCORE: 0.0326

HELIX: 0.002

FCONS_SCORE: 1.6359

RIG_SCORE: 0.9234

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N4109S	TCGA-D8-A142	BRCA	TCGA	IDVFED	LIG_APCC_ABBA_1	0.0833
p.N4109S	DO4984	BRCA	ICGC	IDVFED	LIG_APCC_ABBA_1	0.0833
p.D4096N	TCGA-EE-A3J5	SKCM	TCGA	IDVFED	LIG_APCC_ABBA_1	0.5821
p.D4096N	TCGA-XK-AAIW	PRAD	TCGA	IDVFED	LIG_APCC_ABBA_1	0.5821
p.D4096N	DO233697	GACA	ICGC	IDVFED	LIG_APCC_ABBA_1	0.5821
p.D4096N	DO51407	PRAD	ICGC	IDVFED	LIG_APCC_ABBA_1	0.5821
p.D4096N	DO47331	SKCM	ICGC	IDVFED	LIG_APCC_ABBA_1	0.5821
p.G4104V	DO229045	LICA	ICGC	IDVFED	LIG_APCC_ABBA_1	0.2222
p.N4110T	SIDM00120	Prostate Carcinoma	GDSC	IDVFED	LIG_APCC_ABBA_1	0.0556
p.N4110T	ACH-000979	Prostate Cancer	CCLE	IDVFED	LIG_APCC_ABBA_1	0.0556
p.N4110T	DU-145	prostate	COSMIC	IDVFED	LIG_APCC_ABBA_1	0.0556
p.V4097I	ACH-000170	Non-Cancerous	CCLE	IDVFED	LIG_APCC_ABBA_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07954	Prolow-density lipoprotein receptor-related protein 1	LIG_APCC_ABBA_1	4095:4100	IDVFED	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons