DegronMD - Q9BTA9(WAC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K306Q	TCGA-17-Z026	LUAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation substituting flanking lysine	0.1944
p.S286Y	TCGA-19-5956	GBM	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation blocking phosphorylation signal	0.6389
p.S286Y	DO13863	GBM	ICGC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation blocking phosphorylation signal	0.6389
p.S286C	TCGA-44-7662	LUAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation blocking phosphorylation signal	0.6389
p.Q459E	TCGA-66-2778	LUSC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.0833
p.Q459E	ACH-000975	Lung Cancer	CCLE	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.0833
p.A282T	TCGA-A5-A0G2	UCEC	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.0833
p.T321P	TCGA-A5-A0G2	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.3056
p.A237V	TCGA-AP-A051	UCEC	TCGA	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.2222
p.A237V	DO42673	UCEC	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.2222
p.S318Y	TCGA-AX-A05Z	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.S318Y	DO40884	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.2222
p.D312Y	TCGA-AX-A06F	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.I465M	TCGA-B0-4815	KIRC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.25
p.I465M	TCGA-MV-A51V	BLCA	TCGA	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.25
p.I465M	DO474	BLCA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.25
p.I465M	DO18661	KIRC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.25
p.K290Q	TCGA-CA-6718	COAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.P332L	TCGA-CG-5721	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1667
p.P332L	DO38192	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1667
p.S241I	TCGA-CN-6010	HNSC	TCGA	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.S241I	DO14766	HNSC	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.S241I	DO229045	LICA	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.P464S	TCGA-CV-7568	HNSC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.2222
p.P464S	DO14160	HNSC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.2222
p.P464S	DO222546	MELA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.2222
p.Y187N	TCGA-D1-A15X	UCEC	TCGA	DYR	CBL_MET	186:188	Mutation altering degron motif	0.817
p.Y187N	DO43274	UCEC	ICGC	DYR	CBL_MET	186:188	Mutation altering degron motif	0.817
p.R185M	TCGA-D1-A163	UCEC	TCGA	DYR	CBL_MET	186:188	Mutation rewiring degron network	0.3056
p.R185M	DO41008	UCEC	ICGC	DYR	CBL_MET	186:188	Mutation rewiring degron network	0.3056
p.V315I	TCGA-D3-A8GM	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1389
p.P182T	TCGA-DA-A1IB	SKCM	TCGA	DYR	CBL_MET	186:188	Mutation rewiring degron network	0.2222
p.S180I	TCGA-DX-A6YV	SARC	TCGA	DYR	CBL_MET	186:188	Mutation blocking phosphorylation signal	0.6111
p.P483T	TCGA-EE-A29L	SKCM	TCGA	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1111
p.E304K	TCGA-EY-A1GI	UCEC	TCGA	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1389
p.E304K	DO41211	UCEC	ICGC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1389
p.P322S	TCGA-FS-A1ZZ	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.6752
p.Q223E	TCGA-K4-A54R	BLCA	TCGA	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.Q223E	DO48611	BLCA	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.P315L	DO602	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1389
p.T197S	DO225280	BRCA	ICGC	DYR	CBL_MET	186:188	Mutation blocking phosphorylation signal	0.5278
p.P481R	DO1125	BRCA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1667
p.V336A	DO5074	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.0556
p.V298F	DO229019	LICA	ICGC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V315L	DO229026	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1389
p.C319F	DO229045	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.25
p.S241P	DO229059	LICA	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.P323H	DO23774	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation altering degron motif	0.7694
p.S241C	DO23597	LUAD	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1111
p.N333D	DO35083	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation rewiring degron network	0.1389
p.R477I	DO220070	SARC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.2778
p.R477I	DO47769	STAD	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.2778
p.R468Q	DO219477	SKCM	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation altering degron motif	0.7329
p.R468Q	SNU-81	large intestine	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation altering degron motif	0.7329
p.Q313R	DO39180	THCA	ICGC	PSTSS	DEG_SPOP_SBC_1	322:326	Mutation substituting flanking lysine	0.1944
p.P481L	DO42033	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1667
p.N484Y	DO43226	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.0833
p.A237T	DO41235	UCEC	ICGC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.2222
p.P467L	DO43755	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.3056
p.S225N	SIDM02013	Colorectal Carcinoma	GDSC	DYR	CBL_MET	231:233	Mutation blocking phosphorylation signal	0.6111
p.R230K	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	SIDM00461	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	SIDM01519	Head and Neck Carcinoma	GDSC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	ACH-000786	Lymphoma	CCLE	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	ACH-000992	Head and Neck Cancer	CCLE	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	ACH-001067	Brain Cancer	CCLE	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.R230K	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.3056
p.S296A	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.S296A	SIDM01519	Head and Neck Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.S296A	ACH-000786	Lymphoma	CCLE	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.S296A	ACH-000992	Head and Neck Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.S296A	Daudi	haematopoietic and lymphoid tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.S296A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6477
p.V298L	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V298L	SIDM01519	Head and Neck Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V298L	ACH-000786	Lymphoma	CCLE	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V298L	ACH-000992	Head and Neck Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V298L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.V298L	Daudi	haematopoietic and lymphoid tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.3056
p.N461D	SIDM01412	Oral Cavity Carcinoma	GDSC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1389
p.N461D	ACH-000762	Head and Neck Cancer	CCLE	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1389
p.T293I	SIDM01504	Small Cell Lung Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.8189
p.T293I	ACH-000594	Lung Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.8189
p.R484C	MC116	haematopoietic and lymphoid tissue	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.0833
p.I238K	CAL-51	breast	COSMIC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.1944
p.I283K	CAL-51	breast	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation rewiring degron network	0.1111
p.L459S	AN3-CA	endometrium	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.0833
p.R185K	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	186:188	Mutation rewiring degron network	0.3056
p.R185K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	186:188	Mutation rewiring degron network	0.3056
p.S481T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	468:475	Mutation rewiring degron network	0.1667
p.H229Q	MZ1-PC	pancreas	COSMIC	DYR	CBL_MET	231:233	Mutation rewiring degron network	0.2778
p.A292V	SNU-1040	large intestine	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	291:297	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WAC

UniProt ID: Q9BTA9

Entrez ID: 51322

Protein name: WW domain-containing adapter protein with coiled-coil

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WAC in