DegronMD

Uniprot ID: Q9BTA9

Source protein: WW domain-containing adapter protein with coiled-coil

Source gene: WAC

Class: DEG_SCF_FBW7_1

Location: 291:297

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 90.4429

COIL: 0.9634

CONS_SCORE: 0.422

DSS_SCORE: 0.6815

HELIX: 0.0153

FCONS_SCORE: 1.0243

RIG_SCORE: 0.6217

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T293I	SIDM01504	Small Cell Lung Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	0.8189
p.T293I	ACH-000594	Lung Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	0.8189
p.A292V	SNU-1040	large_intestine	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.6936
p.S296A	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S296A	SIDM01519	Head and Neck Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S296A	ACH-000786	Lymphoma	CCLE	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S296A	ACH-000992	Head and Neck Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S296A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S296A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.6477
p.S286Y	TCGA-19-5956	GBM	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.6389
p.S286Y	DO13863	GBM	ICGC	LPTPTSS	DEG_SCF_FBW7_1	0.6389
p.S286C	TCGA-44-7662	LUAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.6389
p.K290Q	TCGA-CA-6718	COAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298F	DO229019	LICA	ICGC	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	SIDM01519	Head and Neck Carcinoma	GDSC	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	ACH-000786	Lymphoma	CCLE	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	ACH-000992	Head and Neck Cancer	CCLE	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.V298L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.3056
p.K306Q	TCGA-17-Z026	LUAD	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.1944
p.E304K	TCGA-EY-A1GI	UCEC	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.1389
p.E304K	DO41211	UCEC	ICGC	LPTPTSS	DEG_SCF_FBW7_1	0.1389
p.I283K	CAL-51	breast	COSMIC	LPTPTSS	DEG_SCF_FBW7_1	0.1111
p.A282T	TCGA-A5-A0G2	UCEC	TCGA	LPTPTSS	DEG_SCF_FBW7_1	0.0833

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Drug responses associated with WAC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LPTPTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTA9	WW domain-containing adapter protein with coiled-coil	DEG_SCF_FBW7_1	291:297	LPTPTSS	FBXW7	0.9891	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPTSS

Degron related mutations and impact score

Drug responses associated with WAC mutations

All proteins holding degron of LPTPTSS