DegronMD

Uniprot ID: Q9BTA9

Source protein: WW domain-containing adapter protein with coiled-coil

Source gene: WAC

Class: DEG_SCF_FBW7_1

Location: 468:475

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 96.375

COIL: 0.9664

CONS_SCORE: 0.3704

DSS_SCORE: 0.5579

HELIX: 0.0138

FCONS_SCORE: 0.8382

RIG_SCORE: 0.6685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q459E	TCGA-66-2778	LUSC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	0.0833
p.Q459E	ACH-000975	Lung Cancer	CCLE	LISTPPVS	DEG_SCF_FBW7_1	0.0833
p.I465M	TCGA-B0-4815	KIRC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	0.25
p.I465M	TCGA-MV-A51V	BLCA	TCGA	LISTPPVS	DEG_SCF_FBW7_1	0.25
p.I465M	DO474	BLCA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.25
p.I465M	DO18661	KIRC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.25
p.P464S	TCGA-CV-7568	HNSC	TCGA	LISTPPVS	DEG_SCF_FBW7_1	0.2222
p.P464S	DO14160	HNSC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.2222
p.P464S	DO222546	MELA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.2222
p.P483T	TCGA-EE-A29L	SKCM	TCGA	LISTPPVS	DEG_SCF_FBW7_1	0.1111
p.P481R	DO1125	BRCA	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.1667
p.R477I	DO220070	SARC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.2778
p.R477I	DO47769	STAD	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.2778
p.R468Q	DO219477	SKCM	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.7329
p.R468Q	SNU-81	large_intestine	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	0.7329
p.P481L	DO42033	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.1667
p.N484Y	DO43226	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.0833
p.P467L	DO43755	UCEC	ICGC	LISTPPVS	DEG_SCF_FBW7_1	0.3056
p.N461D	SIDM01412	Oral Cavity Carcinoma	GDSC	LISTPPVS	DEG_SCF_FBW7_1	0.1389
p.N461D	ACH-000762	Head and Neck Cancer	CCLE	LISTPPVS	DEG_SCF_FBW7_1	0.1389
p.R484C	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	0.0833
p.L459S	AN3-CA	endometrium	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	0.0833
p.S481T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LISTPPVS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTA9	WW domain-containing adapter protein with coiled-coil	DEG_SCF_FBW7_1	468:475	LISTPPVS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons