DegronMD - Q8WVM8(SCFD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D266N	TCGA-06-5416	GBM	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.2222
p.R567I	TCGA-06-5416	GBM	TCGA	DYR	CBL_MET	565:567	Mutation altering degron motif	0.8102
p.L260I	TCGA-AP-A0LM	UCEC	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation altering degron motif	0.6063
p.M68I	TCGA-BA-5151	HNSC	TCGA	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1667
p.R575W	TCGA-BR-4280	STAD	TCGA	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1111
p.R575W	TCGA-D5-6930	COAD	TCGA	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1111
p.R575W	SIDM01278	Colorectal Carcinoma	GDSC	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1111
p.D244N	TCGA-E9-A2JT	BRCA	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.E244Q	DO228331	BRCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.E262K	DO1076	BRCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation altering degron motif	0.7022
p.R82L	DO228986	LICA	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.25
p.S255C	DO25767	LUAD	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation altering degron motif	0.7541
p.R86M	DO23561	LUAD	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1389
p.L64F	DO26445	LUSC	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0556
p.V79A	DO232224	PBCA	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6936
p.E244V	DO229253	THCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.A83V	DO43306	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.2222
p.A83V	DO43755	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.2222
p.R82C	DO41999	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.25
p.R82C	DO41133	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.25
p.D565E	SIDM01248	Thyroid Gland Carcinoma	GDSC	DYR	CBL_MET	565:567	Mutation altering degron motif	0.6758
p.D565E	ACH-001023	Thyroid Cancer	CCLE	DYR	CBL_MET	565:567	Mutation altering degron motif	0.6758
p.D565E	CGTH-W-1	thyroid	COSMIC	DYR	CBL_MET	565:567	Mutation altering degron motif	0.6758
p.S78T	SIDM01045	Endometrial Carcinoma	GDSC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6005
p.S78T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6005
p.S78T	EN	endometrium	COSMIC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6005
p.N560T	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1944
p.N560T	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1944
p.N560H	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1944
p.N560H	ACH-000220	Lymphoma	CCLE	DYR	CBL_MET	565:567	Mutation rewiring degron network	0.1944
p.V79F	NCI-H747	large intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.7068
p.A67P	SNU-1040	large intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.1389
p.A64G	C2BBe1	large intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation rewiring degron network	0.0556
p.A271V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0833
p.R244T	GI-1	central nervous system	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.K78N	LS-411N	large intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	74:79	Mutation altering degron motif	0.6918
p.A246V	KCL-22	haematopoietic and lymphoid tissue	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1111

Kaplan plot for SCFD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCFD1

UniProt ID: Q8WVM8

Entrez ID: 23256

Protein name: Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCFD1 in