DegronMD

Uniprot ID: Q8WVM8

Source protein: Sec1 family domain-containing protein 1

Source gene: SCFD1

Class: DEG_APCC_DBOX_1

Location: 254:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6182

ASA_SCORE: 29.4778

COIL: 0.3944

CONS_SCORE: 0.732

DSS_SCORE: 0.0558

HELIX: 0.0239

FCONS_SCORE: 1.5419

RIG_SCORE: 0.9129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D266N	TCGA-06-5416	GBM	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	0.2222
p.L260I	TCGA-AP-A0LM	UCEC	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	0.6063
p.D244N	TCGA-E9-A2JT	BRCA	TCGA	QRPLLVLVD	DEG_APCC_DBOX_1	0.0556
p.E244Q	DO228331	BRCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	0.0556
p.E262K	DO1076	BRCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	0.7022
p.S255C	DO25767	LUAD	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	0.7541
p.E244V	DO229253	THCA	ICGC	QRPLLVLVD	DEG_APCC_DBOX_1	0.0556
p.A271V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	0.0833
p.R244T	GI-1	central_nervous_system	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	0.0556
p.A246V	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	QRPLLVLVD	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVM8	Sec1 family domain-containing protein 1	DEG_APCC_DBOX_1	254:262	QRPLLVLVD	APC,CDC20,FZR1	0.6182	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons