DegronMD

Uniprot ID: Q8WVM8

Source protein: Sec1 family domain-containing protein 1

Source gene: SCFD1

Class: LIG_APCC_ABBA_1

Location: 74:79

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5394

ASA_SCORE: 77.6167

COIL: 0.684

CONS_SCORE: 0.5025

DSS_SCORE: 0.1441

HELIX: 0.0352

FCONS_SCORE: 0.7133

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M68I	TCGA-BA-5151	HNSC	TCGA	LLLHSD	LIG_APCC_ABBA_1	0.1667
p.R82L	DO228986	LICA	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.25
p.R86M	DO23561	LUAD	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.1389
p.L64F	DO26445	LUSC	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.0556
p.V79A	DO232224	PBCA	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.6936
p.A83V	DO43306	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.2222
p.A83V	DO43755	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.2222
p.R82C	DO41999	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.25
p.R82C	DO41133	UCEC	ICGC	LLLHSD	LIG_APCC_ABBA_1	0.25
p.S78T	SIDM01045	Endometrial Carcinoma	GDSC	LLLHSD	LIG_APCC_ABBA_1	0.6005
p.S78T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LLLHSD	LIG_APCC_ABBA_1	0.6005
p.S78T	EN	endometrium	COSMIC	LLLHSD	LIG_APCC_ABBA_1	0.6005
p.V79F	NCI-H747	large_intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	0.7068
p.A67P	SNU-1040	large_intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	0.1389
p.A64G	C2BBe1	large_intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	0.0556
p.K78N	LS-411N	large_intestine	COSMIC	LLLHSD	LIG_APCC_ABBA_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WVM8	Sec1 family domain-containing protein 1	LIG_APCC_ABBA_1	74:79	LLLHSD	APC,CDC20,FZR1	0.5394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons